Reduction of acethylcolinesterase activity in the brain of mdx mice

dc.creatorCOMIM, Clarissa M.
dc.creatorMORAZ, Thais
dc.creatorABREU, Igor
dc.creatorFRAGA, Daiane B.
dc.creatorGHEDIM, Fernando V.
dc.creatorMILDNER, Natalia
dc.creatorTUON, Lisiane
dc.creatorVAINZOF, Mariz
dc.creatorZUGNO, Alexandra I.
dc.creatorQUEVEDO, Joao
dc.date.accessioned2012-10-20T03:04:13Z
dc.date.accessioned2018-07-04T15:32:28Z
dc.date.available2012-10-20T03:04:13Z
dc.date.available2018-07-04T15:32:28Z
dc.date.created2012-10-20T03:04:13Z
dc.date.issued2011
dc.identifierNEUROMUSCULAR DISORDERS, v.21, n.5, p.359-362, 2011
dc.identifier0960-8966
dc.identifierhttp://producao.usp.br/handle/BDPI/27559
dc.identifier10.1016/j.nmd.2011.02.017
dc.identifierhttp://dx.doi.org/10.1016/j.nmd.2011.02.017
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1624206
dc.description.abstractLack of dystrophin in brain structures have been involved with impaired cognitive functions. Acethylcolinesterase (AChE) is implicated in many cognitive functions and probably plays important roles in neurodegenerative disorders. In the present study, we investigated AChE activity in the prefrontal cortex, hippocampus, striatum and cortex of mdx mice. To this aim, brain tissues from male dystrophic mdx and normal control mice were used. We observed that mdx mice display a reduction in AChE activity of 40-60% in all brain structures evaluated. In conclusion, dystrophin deficiency may be affecting AChE activity and contributing negatively, in part, to memory storage and restoring. (C) 2011 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relationNeuromuscular Disorders
dc.rightsCopyright PERGAMON-ELSEVIER SCIENCE LTD
dc.rightsrestrictedAccess
dc.subjectmdx
dc.subjectBrain
dc.subjectAcethylcolinesterase
dc.titleReduction of acethylcolinesterase activity in the brain of mdx mice
dc.typeArtículos de revistas


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