Artículos de revistas
Temporal lobe epilepsy and social behavior: An animal model
Fecha
2008Registro en:
EPILEPSY & BEHAVIOR, v.13, n.1, p.43-46, 2008
1525-5050
10.1016/j.yebeh.2008.03.004
Autor
MARIN, Joao Carlos M.
MOURA, Paula J.
CYSNEIROS, Roberta M.
COLUGNATI, Diego B.
CAVALHEIRO, Esper A.
SCORZA, Fulvio A.
XAVIER, Gilberto F.
ZILBOVICIUS, Monica
MERCADANTE, Marcos T.
Institución
Resumen
Social behavior depends on the integrity of social brain circuitry. The temporal lobe is an important part of the social brain, and manifests morphological and functional alterations in autism spectrum disorders (ASD). Rats with temporal lobe epilepsy (TLE), induced with pilocarpine, were subjected to a social discrimination test that has been used to investigate potential animal models of ASD, and the results were compared with those for the control group. Rats with TLE exhibited fewer social behaviors than controls. No differences were observed in nonsocial behavior between groups. The results suggest an important role for the temporal lobe in regulating social behaviors. This animal model might be used to explore some questions about ASD pathophysiology. (c) 2008 Elsevier Inc. All rights reserved.