dc.creator | GUGLIUCCI, Alejandro | |
dc.creator | BASTOS, Deborah H. Markowicz | |
dc.date.accessioned | 2012-10-20T01:31:31Z | |
dc.date.accessioned | 2018-07-04T15:27:58Z | |
dc.date.available | 2012-10-20T01:31:31Z | |
dc.date.available | 2018-07-04T15:27:58Z | |
dc.date.created | 2012-10-20T01:31:31Z | |
dc.date.issued | 2009 | |
dc.identifier | FITOTERAPIA, v.80, n.2, p.138-142, 2009 | |
dc.identifier | 0367-326X | |
dc.identifier | http://producao.usp.br/handle/BDPI/26628 | |
dc.identifier | 10.1016/j.fitote.2009.01.001 | |
dc.identifier | http://dx.doi.org/10.1016/j.fitote.2009.01.001 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1623287 | |
dc.description.abstract | We hypothesized that chlorogenic acids, the main phenolics in coffee, many fruits and Ilex paraguariensis extracts, protect paraoxonase 1 activity in HDL from inactivation by chlorination at concentrations of HOCl (50 mu M) and chlorogenic acid (2-10 mu M) compatible with those found in humans. When human HDL was incubated in the presence of HOCl/OCl-, a concentration dependent loss of activity was apparent. Of interest, 5 caffeoylquinic acid at 5 mu mol/L affords more than 60% protection of the activity reaching 100% at 25 mu mol/L. This compound and the plant sources that are rich in them may be protectors of paraoxonase 1 activity. (C) 2009 Elsevier B.V. All rights reserved. | |
dc.language | eng | |
dc.publisher | ELSEVIER SCIENCE BV | |
dc.relation | Fitoterapia | |
dc.rights | Copyright ELSEVIER SCIENCE BV | |
dc.rights | restrictedAccess | |
dc.subject | Chlorogenic acid | |
dc.subject | Polyphenols | |
dc.subject | Ilex paraguariensis | |
dc.subject | Myeloperoxidase | |
dc.subject | Chlorination | |
dc.subject | Chlorotyrosine | |
dc.title | Chlorogenic acid protects paraoxonase 1 activity in high density lipoprotein from inactivation caused by physiological concentrations of hypochlorite | |
dc.type | Artículos de revistas | |