Artículos de revistas
Effects of Cadmium on the Rat Salivary Glands, During Lactation
Fecha
2009Registro en:
INTERNATIONAL JOURNAL OF MORPHOLOGY, v.27, n.4, p.1129-1137, 2009
0717-9502
Autor
FRIEDRICHI, Christiane
LOPES, Ruberval Armando
SALA, Miguel Angel
FELIPPINI, Ana Luiza de C.
ISSA, Joao Paulo M.
WATANABE, Ii-Sei
LOPES, Tulio Roberto V. P.
Institución
Resumen
Cadmium (Cd) in air, drinking water and food has the potential to affect the health of people, mainly those who live in highly industrialized regions. Cd affects placental function, can cross the placental barrier and directly modify fetal development. Once the organism is particularly susceptible to the exposition to the Cd during the perinatal period, and that this metal can be excreted in the milk, the aim of the present work was to study the effects of the constant exposition to drinkable water containing low levels of Cd during the lactation, on the salivary glands of the rat. Female rats received ad libitum drinking water containing 300mg/l of CdCl2 throughout the whole lactation. Control animals received a similar volume of water without Cd. Lactant rats (21 day old) were killed by lethal dose of anesthetic. The salivary glands were separated, fixed in ""alfac"" solution for 24 h, and serially sectioned. The 6 mu m thick sections were stained with hematoxylin and eosin. Nuclear glandular parameters were estimated, as well as cytoplasm and cell volume, nucleus/cytoplasm ratio, number and surface density, diameters and cell thickness. Mean body weight was 34.86 g for the control group and 18.56 g for the Cd-treated group. Histologically, the glandular acini were significantly smaller, the gland ducts were similar in both groups studied. The connective tissue was more abundant. In conclusion, the salivary glands (submandibular, parotid and sublingual) showed retarded growth after Cd intoxication.