dc.creatorSANTOS, Giscle Caravina
dc.creatorCARVALHO, Katia Candido
dc.creatorFALZONI, Roberto
dc.creatorSIMOES, Ana Carolina Q.
dc.creatorROCHA, Rafael Malagoli
dc.creatorLOPES, Ademar
dc.creatorVASSALLO, Jose
dc.creatorREIS, Luiz Fernando Lima
dc.creatorSOARES, Fernando Augusto
dc.creatorCUNHA, Isabela Werneck da
dc.date.accessioned2012-10-20T00:16:44Z
dc.date.accessioned2018-07-04T15:23:30Z
dc.date.available2012-10-20T00:16:44Z
dc.date.available2018-07-04T15:23:30Z
dc.date.created2012-10-20T00:16:44Z
dc.date.issued2009
dc.identifierMODERN PATHOLOGY, v.22, n.10, p.1321-1327, 2009
dc.identifier0893-3952
dc.identifierhttp://producao.usp.br/handle/BDPI/25707
dc.identifier10.1038/modpathol.2009.99
dc.identifierhttp://dx.doi.org/10.1038/modpathol.2009.99
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1622372
dc.description.abstractGlial fibrillary acidic protein (GFAP) is a member of the intermediary filament protein family. It is an important component of astrocytes and a known diagnostic marker of glial differentiation. GFAP is expressed in other neural tumors and pleomorphic adenoma and, less frequently, in cartilage tumors, chordomas, and soft tissue myoepitheliomas. The aim of this study was to evaluate the role of GFAP and its reliability in nonglial tumors as an immunohistochemical marker. We evaluated GFAP gene and protein expression using Q-PCR and immunohistochemistry, respectively, in 81 and 387 cases of soft tissue, bone tumors, and salivary pleomorphic adenomas. Immunohistochemistry staining for GFAP was observed in all osteosarcomas (8 cases), all pleomorphic adenomas (7 cases), in 5 of 6 soft tissue myoepitheliomas, and in 21 of 76 chondrosarcomas. By Q-PCR, GFAP was highly expressed in pleomorphic adenomas and, to a lesser extent, chondrosarcomas, soft tissue myoepitheliomas, and chondroblastic osteosarcomas. The results that we obtained by immunohistochemistry and Q-PCR were well correlated. GFAP is a potential marker for tumors with cartilaginous differentiation, supported by evidence that GFAP is expressed in certain cases of myoepithelial tumors by immunohistochemistry, including soft tissue myoepitheliomas, which are related to cartilaginous differentiation. These findings contribute significantly to the diagnosis of soft tissue myoepitheliomas with cartilaginous differentiation and chondroblastic osteosarcoma in mesenchymal tumors. Modern Pathology ( 2009) 22, 1321-1327; doi: 10.1038/modpathol.2009.99; published online 7 August 2009
dc.languageeng
dc.publisherNATURE PUBLISHING GROUP
dc.relationModern Pathology
dc.rightsCopyright NATURE PUBLISHING GROUP
dc.rightsrestrictedAccess
dc.subjectmesenchymal tumors
dc.subjectcartilaginous differentiation
dc.subjectGFAP
dc.subjectimmunohistochemistry
dc.subjectQ-PCR
dc.titleGlial fibrillary acidic protein in tumor types with cartilaginous differentiation
dc.typeArtículos de revistas


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