dc.creatorOLIVEIRA, Carolina Dizioli Rodrigues
dc.creatorMOREIRA, Camila Queiroz
dc.creatorSA, Lilian Rose Marques de
dc.creatorSPINOSA, Helenice de Souza
dc.creatorYONAMINE, Mauricio
dc.date.accessioned2012-10-19T23:54:35Z
dc.date.accessioned2018-07-04T15:21:56Z
dc.date.available2012-10-19T23:54:35Z
dc.date.available2018-07-04T15:21:56Z
dc.date.created2012-10-19T23:54:35Z
dc.date.issued2010
dc.identifierBIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY, v.89, n.3, p.207-212, 2010
dc.identifier1542-9733
dc.identifierhttp://producao.usp.br/handle/BDPI/25380
dc.identifier10.1002/bdrb.20244
dc.identifierhttp://dx.doi.org/10.1002/bdrb.20244
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1622082
dc.description.abstractINTRODUCTION: Ayahuasca is a psychotropic plant beverage initially used by shamans throughout the Amazon region during traditional religious cult. In recent years, ayahuasca has also been used in ceremonies of a number of modern syncretic religious groups, including pregnant women. However, no documented study has been performed to evaluate the risk of developmental toxicity of ayahuasca. METHODS: In the present work, maternal and developmental toxicity was evaluated in Wistar rats. Ayahuasca was administered to pregnant rats in three different doses [the equivalent typical dose (TD) administered to humans, five-fold TD and 10-fold TD] during the gestational period (6-20 days). RESULTS: Dams treated with the highest ayahuasca dose showed maternal toxicity with decrease of weight gain and food intake. Visceral fetal findings were observed in all treatment groups. Skeletal findings were observed in the intermediate- and high-dose groups. The fetuses deriving from the highest dose group also presented a decrease in body weight. CONCLUSIONS: From these results, it is possible to conclude that there is a risk of maternal and developmental toxicity following ayahuasca exposure and that the level of toxicity appears to be dose-dependent. Birth Defects Res (Part B) 89:207-212, 2010. (C) 2010 Wiley-Liss, Inc.
dc.languageeng
dc.publisherWILEY-BLACKWELL
dc.relationBirth Defects Research Part B-developmental and Reproductive Toxicology
dc.rightsCopyright WILEY-BLACKWELL
dc.rightsrestrictedAccess
dc.subjectayahuasca
dc.subjectPsychotria viridis
dc.subjectBanisteriopsis caapi
dc.subjectteratogenicity
dc.subjectmaternal toxicity
dc.subjectrats
dc.titleMaternal and Developmental Toxicity of Ayahuasca in Wistar Rats
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución