Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse

dc.creatorFROTA, Elizabeth Regina Comini
dc.creatorRODRIGUES, David Henrique
dc.creatorDONADI, Eduardo Antonio
dc.creatorBRUM, Doralina G.
dc.creatorMACIEL, Damacio Ramon Kaimen
dc.creatorTEIXEIRA, Antonio Lucio
dc.date.accessioned2012-10-19T23:34:10Z
dc.date.accessioned2018-07-04T15:19:37Z
dc.date.available2012-10-19T23:34:10Z
dc.date.available2018-07-04T15:19:37Z
dc.date.created2012-10-19T23:34:10Z
dc.date.issued2009
dc.identifierNEUROSCIENCE LETTERS, v.460, n.2, p.130-132, 2009
dc.identifier0304-3940
dc.identifierhttp://producao.usp.br/handle/BDPI/24901
dc.identifier10.1016/j.neulet.2009.05.057
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2009.05.057
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1621627
dc.description.abstractBrain derived neurotrophic factor (BDNF) has been related to neuroprotection in a series of central nervous system diseases, although its role in multiple sclerosis (MS) was only partially investigated. In this work, we aimed to evaluate the plasma levels of BDNF from 29 MS patients and 24 control subjects. MS patients had decreased levels of BDNF in comparison with healthy controls. BDNF levels increased significantly after MS relapse. Our results provide some evidence for the involvement of BDNF in the pathogenesis of MS and suggest a role for this neurotrophin during the recovery of acute demyelinating inflammatory lesion. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
dc.languageeng
dc.publisherELSEVIER IRELAND LTD
dc.relationNeuroscience Letters
dc.rightsCopyright ELSEVIER IRELAND LTD
dc.rightsrestrictedAccess
dc.subjectNeurotrophins
dc.subjectBrain derived neurotrophic factor
dc.subjectMultiple sclerosis
dc.subjectNeuroprotection
dc.titleIncreased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse
dc.typeArtículos de revistas


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