dc.creatorSCHIAVON, Anglica P.
dc.creatorMILANI, Humberto
dc.creatorROMANINI, Cassia V.
dc.creatorFORESTI, Maira Licia
dc.creatorCASTRO, Olagide W.
dc.creatorGARCIA-CAIRASCO, Norberto
dc.creatorOLIVEIRA, Rubia M. W. de
dc.date.accessioned2012-10-19T23:33:58Z
dc.date.accessioned2018-07-04T15:19:29Z
dc.date.available2012-10-19T23:33:58Z
dc.date.available2018-07-04T15:19:29Z
dc.date.created2012-10-19T23:33:58Z
dc.date.issued2010
dc.identifierNEUROSCIENCE LETTERS, v.470, n.1, p.43-48, 2010
dc.identifier0304-3940
dc.identifierhttp://producao.usp.br/handle/BDPI/24867
dc.identifier10.1016/j.neulet.2009.12.052
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2009.12.052
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1621593
dc.description.abstractThis study was aimed to determine whether imipramine chronic treatment promotes neurogenesis in the dentate gyrus (DG) and interferes with neuronal death in the CA1 subfield of the hippocampus after transient global cerebral ischemia (TGCI) in rats. After TGCI, animals were treated with imipramine (20 mg/kg, i.p.) or saline during 14 days. 5-Bromo-2`-deoxyuridine-5`-monophosphate (BrdU) was injected 24 h after the last imipramine or saline injection to label proliferating cells. In order to confirm the effect of TGCI on neuronal death and cell proliferation, a group of animals was sacrificed 7 days after TGCI. Neurogenesis and neurodegeneration were evaluated by doublecortin (DCX)-immunohistochemistry and Fluoro-Jade C (FJC)- staining, respectively. The rate of cell proliferation increases 7 days but returns to basal levels 14 days after TGCI. There was a significant increase in the number of FJC-positive neurons in the CA1 of animals 7 and 14 days after TGCI. Chronic imipramine treatment increased cell proliferation in the SGZ of DG and reduced the neurodegeneration in the CA] of the hippocampus 14 days after TGCI. Immunohistochemistry for DCX detected an increased number of newly generated neurons in the hippocampal DG 14 days after TGCI, which was not affected by imipramine treatment. Further studies are needed to evaluate whether imipramine treatment for longer time would be able to promote survival of newly generated neurons as well as to improve functional recovery after TGCI. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
dc.languageeng
dc.publisherELSEVIER IRELAND LTD
dc.relationNeuroscience Letters
dc.rightsCopyright ELSEVIER IRELAND LTD
dc.rightsrestrictedAccess
dc.subjectTransitory global cerebral ischemia
dc.subjectImipramine
dc.subjectNeurogenesis
dc.subjectFluoro-Jade C
dc.subjectHippocampus
dc.subjectRats
dc.titleImipramine enhances cell proliferation and decreases neurodegeneration in the hippocampus after transient global cerebral ischemia in rats
dc.typeArtículos de revistas


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