dc.creatorCARMONA, Fabio
dc.creatorMANSO, Paulo H.
dc.creatorVICENTE, Walter V. A.
dc.creatorCASTRO, Margaret
dc.creatorCARLOTTI, Ana P. C. P.
dc.date.accessioned2012-10-19T23:33:36Z
dc.date.accessioned2018-07-04T15:19:22Z
dc.date.available2012-10-19T23:33:36Z
dc.date.available2018-07-04T15:19:22Z
dc.date.created2012-10-19T23:33:36Z
dc.date.issued2008
dc.identifierCYTOKINE, v.42, n.3, p.317-324, 2008
dc.identifier1043-4666
dc.identifierhttp://producao.usp.br/handle/BDPI/24837
dc.identifier10.1016/j.cyto.2008.03.005
dc.identifierhttp://dx.doi.org/10.1016/j.cyto.2008.03.005
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1621563
dc.description.abstractLow cardiac output syndrome (LCOS) is a common problem following cardiac surgery with cardiopulmonary bypass (CPB) in neonates and infants, and its early recognition remains a challenging task. We aimed to test whether a multimarker approach combining inflammatory and cardiac markers provides complementary information for prediction of LCOS and death in children submitted to cardiac surgery with CPB. Forty-six children younger than 18 months with congenital heart defects were prospectively enrolled. No intervention was made. Blood samples were collected pre-operatively, during CPB and post-operatively (PO) for measurement of interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor (TNF)-alpha, cardiac troponin I (cTnI) and N-terminal pro-B-type natriuretic peptide (NT-proBNP). Clinical data and outcome variables were recorded. Logistic regression was used to identify predictors of LCOS and death. Multivariate logistic regression identified pre-operative NT-proBNP and IL-8 4 h PO as independent predictors of LCOS, while cTnI 4 h PO and CPB length were independent predictors of death. The use of inflammatory and cardiac markers in combination improved sensitivity, negative predictive value and accuracy of the models. In conclusion, the combined assessment of inflammatory and cardiac biochemical markers can be useful for identifying young children at increased risk for LCOS and death after heart surgery with CPB. (C) 2008 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
dc.relationCytokine
dc.rightsCopyright ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
dc.rightsrestrictedAccess
dc.subjectcongenital heart defects
dc.subjectcardiopulmonary bypass
dc.subjectlow cardiac output syndrome
dc.subjectinflammation
dc.subjectnatriuretic peptides
dc.titleRisk stratification in neonates and infants submitted to cardiac surgery with cardiopulmonary bypass: A multimarker approach combining inflammatory mediators, N-terminal pro-B-type natriuretic peptide and troponin I
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución