dc.creator | UENO, Linda M. | |
dc.creator | DRAGER, Luciano F. | |
dc.creator | RODRIGUES, Ana C. T. | |
dc.creator | RONDON, Maria U. P. B. | |
dc.creator | MATHIAS JR., Wilson | |
dc.creator | KRIEGER, Eduardo M. | |
dc.creator | FAZAN JUNIOR, Rubens | |
dc.creator | NEGRAO, Carlos E. | |
dc.creator | LORENZI-FILHO, Geraldo | |
dc.date.accessioned | 2012-10-19T22:53:51Z | |
dc.date.accessioned | 2018-07-04T15:17:19Z | |
dc.date.available | 2012-10-19T22:53:51Z | |
dc.date.available | 2018-07-04T15:17:19Z | |
dc.date.created | 2012-10-19T22:53:51Z | |
dc.date.issued | 2011 | |
dc.identifier | INTERNATIONAL JOURNAL OF CARDIOLOGY, v.148, n.1, p.53-58, 2011 | |
dc.identifier | 0167-5273 | |
dc.identifier | http://producao.usp.br/handle/BDPI/24374 | |
dc.identifier | 10.1016/j.ijcard.2009.10.023 | |
dc.identifier | http://dx.doi.org/10.1016/j.ijcard.2009.10.023 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1621102 | |
dc.description.abstract | Introduction: Among patients with congestive heart failure (CHF) both obstructive and central sleep apnea (SA) are associated with increased sympathetic activity. However, the day-night pattern of cardiac autonomic nervous system modulation in CHF patients with and without sleep apnea is unknown. Material and methods: Twenty-five CHF patients underwent polysomnography with simultaneous beat-to-beat blood pressure (Portapres), respiration and electrocardiogram monitoring. Patients were divided according to the presence (SA, n=17) and absence of SA (NoSA, n=8). Power spectral analyses of heart rate variability (HRV) and spontaneous baroreflex sensitivity (BRS) were determined in periods with stable breathing while awake at 6 AM, 10 AM, 10 PM, as well as during stage 2 sleep. In addition, muscle sympathetic nerve activity (MSNA) was evaluated at 10 AM. Results: RR variance, low-frequency (LF), high-frequency (HF) powers of HRV, and BRS were significantly lower in patients with SA compared with NoSA in all periods. HF power, a marker of vagal activity, increased during sleep in patients with NoSA but in contrast did not change across the 24-hour period in patients with SA. MSNA was significantly higher in patients with SA compared with NoSA. RR variance, LF and HF powers correlated inversely with simultaneous MSNA (r=-0.64, -0.61, and -0.61 respectively; P < 0.01). Conclusions: Patients with CHF and SA present a reduced and blunted cardiac autonomic modulation across the 24-hour period. These findings may help to explain the increased cardiovascular risk in patients with CHF and SA. (C) 2009 Elsevier Ireland Ltd. All rights reserved. | |
dc.language | eng | |
dc.publisher | ELSEVIER IRELAND LTD | |
dc.relation | International Journal of Cardiology | |
dc.rights | Copyright ELSEVIER IRELAND LTD | |
dc.rights | restrictedAccess | |
dc.subject | Chronic heart failure | |
dc.subject | Sleep apnea | |
dc.subject | Cardiac autonomic control | |
dc.subject | Spontaneous baroreflex sensitivity | |
dc.title | Day-night pattern of autonomic nervous system modulation in patients with heart failure with and without sleep apnea | |
dc.type | Artículos de revistas | |