Artículos de revistas
Anticoagulant and fibrinogenolytic properties of the venom of Polybia occidentalis social wasp
Fecha
2010Registro en:
BLOOD COAGULATION & FIBRINOLYSIS, v.21, n.7, p.653-659, 2010
0957-5235
10.1097/MBC.0b013e32833cea7a
Autor
CZAIKOSKI, Paula G.
MENALDO, Danilo L.
MARCUSSI, Silvana
BASEGGIO, Anne L. C.
FULY, Andre L.
PAULA, Rafael C.
QUADROS, Andreza U.
ROMAO, Pedro R. T.
BUSCHINI, Maria L. T.
CUNHA, Fernando Q.
SOARES, Andreimar M.
MONTEIRO, Marta C.
Institución
Resumen
Previous studies have shown that venoms of social wasps and bees exhibit strong anticoagulant activity. The present study describes the anticoagulant and fibrinogen-degrading pharmacological properties of the venom of Polybia occidentalis social wasp. The results demonstrated that this venom presented anticoagulant effect, inhibiting the coagulation at different steps of the clotting pathway (intrinsic, extrinsic and common pathway). The venom inhibited platelet aggregation and degraded plasma fibrinogen, possibly containing metal-dependent metalloproteases that specifically cleave the B beta-chain of fibrinogen. In conclusion, fibrinogenolytic and anticoagulant properties of this wasp venom find a potential application in drug development for the treatment of thrombotic disorders. For that, further studies should be carried out in order to identify and isolate the active compounds responsible for these effects. Blood Coagul Fibrinolysis 21: 653-659 (c) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.