dc.creator | DEOLINDO, Milena | |
dc.creator | PELOSI, Gislaine Garcia | |
dc.creator | TAVARES, Rodrigo Fiacadori | |
dc.creator | CORRA, Fernando Morgan Aguiar | |
dc.date.accessioned | 2012-10-19T22:52:19Z | |
dc.date.accessioned | 2018-07-04T15:16:52Z | |
dc.date.available | 2012-10-19T22:52:19Z | |
dc.date.available | 2018-07-04T15:16:52Z | |
dc.date.created | 2012-10-19T22:52:19Z | |
dc.date.issued | 2008 | |
dc.identifier | NEUROSCIENCE LETTERS, v.430, n.2, p.124-129, 2008 | |
dc.identifier | 0304-3940 | |
dc.identifier | http://producao.usp.br/handle/BDPI/24275 | |
dc.identifier | 10.1016/j.neulet.2007.10.028 | |
dc.identifier | http://dx.doi.org/10.1016/j.neulet.2007.10.028 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1621003 | |
dc.description.abstract | Microinjection Of L-glutamate (L-glu: 1, 3, 10 and 30nmol/100nL) into the lateral hypothalamus (LH) caused dose-related depressor and bradycardiac responses. The cardiovascular response to L-glu stimulation of the LH was blocked by pretreatment of the ventrolateral portion of the periaqueductal gray matter (vIPAG) with CoCl(2) (1 mM/100nL), indicating the existence of a synaptic relay of the hypotensive pathway in that area. Furthermore, the response to L-glu Was blocked by pretreatment of the vIPAG with 2 nmol/100 nL of the selective NMDA-receptor antagonist LY235959 and was not affected by pretreatment with 2 nmol/100 nL of the selective non-NMDA-receptor antagonist NBQX, suggesting a mediation of the hypotensive response by NMDA receptors in the APAG. In conclusion, our results indicate that the hypotensive pathway activated by microinjection Of L-glu into the LH involves a NMDA synaptic relay in the vIPAG. (c) 2007 Elsevier Ireland Ltd. All rights reserved. | |
dc.language | eng | |
dc.publisher | ELSEVIER IRELAND LTD | |
dc.relation | Neuroscience Letters | |
dc.rights | Copyright ELSEVIER IRELAND LTD | |
dc.rights | restrictedAccess | |
dc.subject | lateral hypothalamus | |
dc.subject | Periaqueductal gray | |
dc.subject | L-Glutamate | |
dc.subject | NMDA receptor and cardiovascular system | |
dc.title | The ventrolateral periaqueductal gray is involved in the cardiovascular response evoked by L-glutamate microinjection into the lateral hypothalamus of anesthetized rats | |
dc.type | Artículos de revistas | |