dc.creatorUZUELLI, Juliana A.
dc.creatorDIAS-JUNIOR, Carlos A. C.
dc.creatorTANUS-SANTOS, Jose E.
dc.date.accessioned2012-10-19T22:52:17Z
dc.date.accessioned2018-07-04T15:16:50Z
dc.date.available2012-10-19T22:52:17Z
dc.date.available2018-07-04T15:16:50Z
dc.date.created2012-10-19T22:52:17Z
dc.date.issued2008
dc.identifierCLINICA CHIMICA ACTA, v.388, n.1/Fev, p.184-188, 2008
dc.identifier0009-8981
dc.identifierhttp://producao.usp.br/handle/BDPI/24268
dc.identifier10.1016/j.cca.2007.11.001
dc.identifierhttp://dx.doi.org/10.1016/j.cca.2007.11.001
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1620996
dc.description.abstractBackground: Making the diagnosis of acute pulmonary thromboembolism (APT) and assessing its severity is very challenging, While cardiac troponin I (cTnI) concentrations are promising in risk stratification, no previous study has examined whether there is a linear relation between cTnI concentrations and the severity of APT. Moreover, matrix metalloprotemases (MMPs) are involved in the pathophysiology of APT. However, it is unknown whether the increases in MMP concentrations after APT reflect the severity of this condition. We examined whether the circulating concentrations of these biomarkers increase in proportion to the severity of experimental APT induced in anesthetized dogs. Methods: APT was induced with autologous blood clots (saline, 1, 3, or 5 ml/kg) injected into the right atrium. Hemodynamic evaluations were carried out for 120 min. Gelatin zymography of MMP-2 and MMP-9 from plasma samples were performed and serum cTnI concentrations were determined at baseline and 120 min after APT. Results: While no significant increases in pro-MMP-2 concentrations were found after APT, pro-MMP-9 concentrations increased by 80% only after 5 ml/kg of clot embolization. Serum cTnI and plasma pro-MMP-9 concentrations correlated positively with pulmonary vascular resistance (P=0.007 and rs=0.833 for troponin 1, and P=0.034 and rs=0.684 for pro-MMP-9) and with pulmonary artery pressure (P=0.005 and rs=0.610 for troponin 1, and P=0.022 and rs=0.720 for pro-MMP-9). Conclusions: Circulating cTnI and pro-MMP-9 increase in proportion to the severity of APT, although the increases in plasma pro-MMP-9 are less clear with less severe APT. These findings may be relevant for clinical APT. (C) 2007 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherELSEVIER SCIENCE BV
dc.relationClinica Chimica Acta
dc.rightsCopyright ELSEVIER SCIENCE BV
dc.rightsrestrictedAccess
dc.subjectacute pulmonary embolism
dc.subjectmarkers
dc.subjectmatrix metalloproteinases
dc.subjecttroponin
dc.subjectzymography
dc.titleSeverity dependent increases in circulating cardiac troponin I and MMP-9 concentrations after experimental acute pulmonary thromboembolism
dc.typeArtículos de revistas


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