dc.creatorWICHERT-ANA, Lauro
dc.creatorAZEVEDO-MARQUES, Paulo Mazzoncini de
dc.creatorOLIVEIRA, Lucas Ferrari
dc.creatorTERRA-BUSTAMANTE, Vera Cristina
dc.creatorFERNANDES, Regina Maria Franca
dc.creatorSANTOS, Antonio Carlos
dc.creatorARAUJO, Whemberton Martins
dc.creatorBIANCHIN, Marino Muxfeldt
dc.creatorSIMOES, Marcus Vinicius
dc.creatorSAKAMOTO, Americo Ceiki
dc.date.accessioned2012-10-19T22:49:35Z
dc.date.accessioned2018-07-04T15:15:55Z
dc.date.available2012-10-19T22:49:35Z
dc.date.available2018-07-04T15:15:55Z
dc.date.created2012-10-19T22:49:35Z
dc.date.issued2008
dc.identifierEPILEPSY RESEARCH, v.79, n.1, p.39-48, 2008
dc.identifier0920-1211
dc.identifierhttp://producao.usp.br/handle/BDPI/24059
dc.identifier10.1016/j.eplepsyres.2007.12.018
dc.identifierhttp://dx.doi.org/10.1016/j.eplepsyres.2007.12.018
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1620787
dc.description.abstractObjective: To investigate pathophysiological factors underlying the presence of interictal hyper-perfusion within the limits of the polymicrogyric (PMG) cortex in epileptic patients. Methods: Retrospective observational study on interictal perfusion by Single Photon Emission Computed Tomography (SPECT) in 16 patients with PMG and its correlations with a number of clinical and neurophysiological variables. Patients underwent video-EEG monitoring, neurological and psychiatric assessments, invasive EEG, and the interictal SPECT coregistered to Magnetic Resonance Imaging (MRI). Results: Patients with interictal hyperperfusion within the PMG cortex had a significantly higher spike rate on interictal EEG than patients with normal perfusion. Interictal hyperperfusion was not correlated to sex, age at epilepsy onset, age at evaluation, number of seizures per month, presence of initial precipitating insult (IPI), abnormal neurological examination, EEG findings, ictal serniology, and seizure outcome. The high interictal spike rate did not correlate to a high frequency of seizures per month. Conclusions: Our work provides further evidences for an intrinsic epileptogenesis of the PMG cortex during the interictal state, which accounts for the major rote of PMG tissue in seizure generation. These results might help to increase our understanding about epileptogenesis related to the PMG cortex, providing new toots for more tailored epilepsy surgery in PMG patients. (c) 2008 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherELSEVIER SCIENCE BV
dc.relationEpilepsy Research
dc.rightsCopyright ELSEVIER SCIENCE BV
dc.rightsrestrictedAccess
dc.subjectepilepsy
dc.subjectpolymicrogyria
dc.subjectinterictal SPECT
dc.subjectcoregistration
dc.subjectmalformation
dc.titleInterictal hyperemia correlates with epileptogenicity in polymicrogyric cortex
dc.typeArtículos de revistas


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