dc.creator | BARBIERI, C. L. A. | |
dc.creator | TRONCON, L. E. A. | |
dc.creator | HERCULANO JR., J. R. L. | |
dc.creator | APRILE, L. R. O. | |
dc.creator | MORAES, E. R. | |
dc.creator | SECAF, M. | |
dc.creator | DANTAS, R. O. | |
dc.date.accessioned | 2012-10-19T22:49:34Z | |
dc.date.accessioned | 2018-07-04T15:15:54Z | |
dc.date.available | 2012-10-19T22:49:34Z | |
dc.date.available | 2018-07-04T15:15:54Z | |
dc.date.created | 2012-10-19T22:49:34Z | |
dc.date.issued | 2008 | |
dc.identifier | NEUROGASTROENTEROLOGY AND MOTILITY, v.20, n.5, p.471-478, 2008 | |
dc.identifier | 1350-1925 | |
dc.identifier | http://producao.usp.br/handle/BDPI/24054 | |
dc.identifier | 10.1111/j.1365-2982.2007.01067.x | |
dc.identifier | http://dx.doi.org/10.1111/j.1365-2982.2007.01067.x | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1620782 | |
dc.description.abstract | Disturbed gastric contractility has been found in manometric studies in patients with gastro-oesophageal reflux disease (GORD), but the pathophysiological role of this abnormality is unclear. We aimed at assessing postprandial gastric antral contractions and its relationships with gastric emptying and gastro-oesophageal reflux in GORD patients. Fasted GORD patients (n = 13) and healthy volunteers (n = 13) ingested a liquid meal labelled with 72 MBq of (99m)Technetium-phytate. Gastric images were acquired every 10 min for 2 h, for measuring gastric emptying half time. Dynamic antral scintigraphy (one frame per second), performed for 4 min at 30-min intervals, allowed estimation of both mean dominant frequency and amplitude of antral contractions. In GORD patients (n = 10), acidic reflux episodes occurring 2 h after the ingestion of the same test meal were determined by ambulatory 24-h oesophageal pH monitoring. Gastric emptying was similar in GORD patients and controls (median; range: 82 min; 58-126 vs 80 min; 44-122 min; P = 0.38). Frequency of antral contractions was also similar in both groups (3.1 cpm; 2.8-3.6 vs 3.2 cpm; 2.4-3.8 cpm; P = 0.15). In GORD patients, amplitude of antral contractions was significantly higher than in controls (32.7%; 17-44%vs 23.3%; 16-43%; P = 0.01), and correlated positively with gastric emptying time (R-s = 0.58; P = 0.03) and inversely with the number of reflux episodes (R-s = -0.68; P = 0.02). Increased amplitude of postprandial gastric antral contractions in GORD may comprise a compensatory mechanism against delayed gastric emptying and a defensive factor against acidic gastro-oesophageal reflux. | |
dc.language | eng | |
dc.publisher | BLACKWELL PUBLISHING | |
dc.relation | Neurogastroenterology and Motility | |
dc.rights | Copyright BLACKWELL PUBLISHING | |
dc.rights | restrictedAccess | |
dc.subject | gastric antral contractions | |
dc.subject | gastric emptying | |
dc.subject | gastric motility | |
dc.subject | gastro-oesophageal reflux disease | |
dc.subject | scintigraphy | |
dc.title | Postprandial gastric antral contractions in patients with gastro-oesophageal reflux disease: a scintigraphic study | |
dc.type | Artículos de revistas | |