dc.creator | DEMINICE, Rafael | |
dc.creator | SILVA, Robin P. da | |
dc.creator | LAMARRE, Simon G. | |
dc.creator | BROWN, Colin | |
dc.creator | FUREY, George N. | |
dc.creator | MCCARTER, Shannon A. | |
dc.creator | JORDAO, Alceu Afonso | |
dc.creator | KELLY, Karen B. | |
dc.creator | KING-JONES, Kirst | |
dc.creator | JACOBS, Rene L. | |
dc.creator | BROSNAN, Margaret E. | |
dc.creator | BROSNAN, John T. | |
dc.date.accessioned | 2012-10-19T22:49:28Z | |
dc.date.accessioned | 2018-07-04T15:15:50Z | |
dc.date.available | 2012-10-19T22:49:28Z | |
dc.date.available | 2018-07-04T15:15:50Z | |
dc.date.created | 2012-10-19T22:49:28Z | |
dc.date.issued | 2011 | |
dc.identifier | JOURNAL OF NUTRITION, v.141, n.10, p.1799-1804, 2011 | |
dc.identifier | 0022-3166 | |
dc.identifier | http://producao.usp.br/handle/BDPI/24038 | |
dc.identifier | 10.3945/jn.111.144857 | |
dc.identifier | http://dx.doi.org/10.3945/jn.111.144857 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1620766 | |
dc.description.abstract | The aim of the present study was to examine the effects of creatine supplementation on liver fat accumulation induced by a high-fat diet in rats. Rats were fed 1 of 3 different diets for 3 wk: a control liquid diet (C), a high-fat liquid diet (HF), or a high-fat liquid diet supplemented with creatine (HFC). The C and HF diets contained, respectively, 35 and 71% of energy derived from fat. Creatine supplementation involved the addition of 1% (wt:v) of creatine monohydrate to the liquid diet. The HF diet increased total liver fat concentration, liver TG, and liver TBARS and decreased the hepatic S-adenosylmethionine (SAM) concentration. Creatine supplementation normalized all of these perturbations. Creatine supplementation significantly decreased the renal activity of L-arginine:glycine amidinotransferase and plasma guanidinoacetate and prevented the decrease in hepatic SAM concentration in rats fed the HF diet. However, there was no change in either the phosphatidylcholine:phosphatidylethanolamine (PE) ratio or PE N-methyltransferase activity. The HF diet decreased mRNA for PPAR as well as 2 of its targets, carnitine palmitoyltransferase and long-chain acylCoA dehydrogenase. Creatine supplementation normalized these mRNA levels. In conclusion, creatine supplementation prevented the fatty liver induced by feeding rats a HF diet, probably by normalization of the expression of key genes of beta-oxidation. J. Nutr. 141: 1799-1804, 2011. | |
dc.language | eng | |
dc.publisher | AMER SOC NUTRITIONAL SCIENCE | |
dc.relation | Journal of Nutrition | |
dc.rights | Copyright AMER SOC NUTRITIONAL SCIENCE | |
dc.rights | restrictedAccess | |
dc.title | Creatine Supplementation Prevents the Accumulation of Fat in the Livers of Rats Fed a High-Fat Diet | |
dc.type | Artículos de revistas | |