dc.creator | OLIVEIRA, F. M. de | |
dc.creator | TONE, L. G. | |
dc.creator | SIMOES, B. P. | |
dc.creator | REGO, E. M. | |
dc.creator | MARINATO, A. F. | |
dc.creator | JACOMO, R. H. | |
dc.creator | FALCAO, R. P. | |
dc.date.accessioned | 2012-10-19T22:49:01Z | |
dc.date.accessioned | 2018-07-04T15:15:27Z | |
dc.date.available | 2012-10-19T22:49:01Z | |
dc.date.available | 2018-07-04T15:15:27Z | |
dc.date.created | 2012-10-19T22:49:01Z | |
dc.date.issued | 2009 | |
dc.identifier | INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, v.31, n.4, p.453-456, 2009 | |
dc.identifier | 1751-5521 | |
dc.identifier | http://producao.usp.br/handle/BDPI/23954 | |
dc.identifier | 10.1111/j.1751-553X.2008.01036.x | |
dc.identifier | http://dx.doi.org/10.1111/j.1751-553X.2008.01036.x | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1620682 | |
dc.description.abstract | P>We report a case of T-cell prolymphocytic leukemia (T-PLL) in a 41-year-old male. Classical cytogenetic, spectral karyotyping (SKY) and fluorescence in situ hybridization (FISH) studies of a blood sample obtained at diagnosis revealed the co-existence of t(X;14)(q28;q11), t(Y;14)(q12;q11) and a ring chromosome derivated from i(8)(q10). Immunophenotypic studies revealed involvement of T-cell lineage, with proliferation of CD4(-) CD8(+). The co-existence of two translocations involving both sex chromosomes in a case of T-PLL is rare. Chromosomal instability associated with the disease progression may have allowed the emergence of cell clones with translocations involving the sex chromosomes and the ring chromosome observed. | |
dc.language | eng | |
dc.publisher | WILEY-BLACKWELL PUBLISHING, INC | |
dc.relation | International Journal of Laboratory Hematology | |
dc.rights | Copyright WILEY-BLACKWELL PUBLISHING, INC | |
dc.rights | restrictedAccess | |
dc.subject | t(X | |
dc.subject | 14)(q28 | |
dc.subject | q11) and spectral karyotyping (SKY) | |
dc.subject | t(Y | |
dc.subject | 14)(q12 | |
dc.subject | q11) | |
dc.subject | T-prolymphocytic leukemia (T-PLL) and spectral karyotyping (SKY) | |
dc.title | Translocations t(X;14)(q28;q11) and t(Y;14)(q12;q11) in T-cell prolymphocytic leukemia | |
dc.type | Artículos de revistas | |