dc.creatorLOPES, Lisandro Ferreira
dc.creatorOJOPI, Elida B.
dc.creatorBACCHI, Carlos E.
dc.date.accessioned2012-10-19T18:26:52Z
dc.date.accessioned2018-07-04T15:13:33Z
dc.date.available2012-10-19T18:26:52Z
dc.date.available2018-07-04T15:13:33Z
dc.date.created2012-10-19T18:26:52Z
dc.date.issued2008
dc.identifierPATHOLOGY INTERNATIONAL, v.58, n.6, p.344-352, 2008
dc.identifier1320-5463
dc.identifierhttp://producao.usp.br/handle/BDPI/23526
dc.identifier10.1111/j.1440-1827.2008.02235.x
dc.identifierhttp://dx.doi.org/10.1111/j.1440-1827.2008.02235.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1620256
dc.description.abstractThe aim of the present study was to evaluate the clinicopathological, immunohistochemical, and molecular genetic features of gastrointestinal stromal tumors in Brazil and compare them with cases from other countries. Five hundred and thirteen cases were retrospectively analyzed. HE-stained sections and clinical information were reviewed and the immunohistochemical expression of CD117, CD34, smooth-muscle actin, S-100 protein, desmin, CD44v3 adhesion molecule, p53 protein, epidermal growth factor receptor, and Ki-67 antigen was studied using tissue microarrays. Mutation analysis of KIT and platelet-derived growth factor receptor-alpha genes was also performed. There was a slight female predominance (50.3%) and the median age at diagnosis was 59 years. The tumors were mainly located in the stomach (38.4%). Immunohistochemistry showed that CD117 was expressed in 95.7% of cases. Epidermal growth factor receptor expression was observed in 84.4% of tumors. p53 protein expression was found only in 2.6% of cases but all belonged to the high-risk group for aggressive behavior according to the National Institutes of Health consensus approach. No CD44v3 adhesion molecule expression was detected. KIT exon 11 mutations were the most frequent (62.2%). The present data confirm that gastrointestinal stromal tumors in Brazilian patients do not differ from tumors occurring in other countries.
dc.languageeng
dc.publisherWILEY-BLACKWELL
dc.relationPathology International
dc.rightsCopyright WILEY-BLACKWELL
dc.rightsrestrictedAccess
dc.subjectBrazil
dc.subjectclinicopathological study
dc.subjectgastrointestinal stromal tumor
dc.subjectimmunohistochemistry
dc.subjectmutation analysis
dc.subjecttissue microarray
dc.titleGastrointestinal stromal tumor in Brazil: Clinicopathology, immunohistochemistry, and molecular genetics of 513 cases
dc.typeArtículos de revistas


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