dc.creator | MONTANHEIRO, Patricia | |
dc.creator | OLAH, Ingrid | |
dc.creator | FUKUMORI, Ligia M. I. | |
dc.creator | SMID, Jerusa | |
dc.creator | OLIVEIRA, Augusto Cesar Penalva de | |
dc.creator | KANZAKI, Luis I. B. | |
dc.creator | FONSECA, Luiz Augusto M. | |
dc.creator | DUARTE, Alberto J. S. | |
dc.creator | CASSEB, Jorge | |
dc.date.accessioned | 2012-10-19T18:26:49Z | |
dc.date.accessioned | 2018-07-04T15:13:31Z | |
dc.date.available | 2012-10-19T18:26:49Z | |
dc.date.available | 2018-07-04T15:13:31Z | |
dc.date.created | 2012-10-19T18:26:49Z | |
dc.date.issued | 2008 | |
dc.identifier | VIRUS RESEARCH, v.135, n.1, p.22-25, 2008 | |
dc.identifier | 0168-1702 | |
dc.identifier | http://producao.usp.br/handle/BDPI/23518 | |
dc.identifier | 10.1016/j.virusres.2008.01.015 | |
dc.identifier | http://dx.doi.org/10.1016/j.virusres.2008.01.015 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1620248 | |
dc.description.abstract | Background: HTLV-2 infections are almost always asymptomatic, and diseases associated with the infection are rarely reported. Little information is available on the relationship between HTLV-2 proviral load and gender or expression of disease, especially among patients with HlV-1 co-infection. Methods: We studied 77 HTLV-2-infected subjects followed in our clinic for the last 9 years; 53 (69%) of them were co-infected with HIV-1. HTLV-2 DNA proviral load (PVL) was measured by real time PCR, a test with a sensitivity of 10 in 10(4) PBMCs. Results: Six of 53 HTLV-2/HIV-1 cases had a myelopathy (all of them had undetectable PVL of HTLV-2). Only 3 of 35 women (2 out of 3 co-infected with HIV) had a detectable PVL, whereas 10 of 42 men had a detectable PVL. Regardless of their HIV status women had significantly lower PVL than men (10 vs. 43 CopieS/10(4) PBMCs, p < 0.05). Conclusions: We noticed the occurrence of myelopathy in HTLV-2/HIV-1 co-infected patients, with undetectable HTLV-2 viral load. There was a sex difference in viral load for HTLV-2, what may be the result in mode of transmission or acquisition of the virus. (c) 2008 Elsevier B. V. All rights reserved. | |
dc.language | eng | |
dc.publisher | ELSEVIER SCIENCE BV | |
dc.relation | Virus Research | |
dc.rights | Copyright ELSEVIER SCIENCE BV | |
dc.rights | restrictedAccess | |
dc.subject | HTLV-2 | |
dc.subject | IDU | |
dc.subject | FHV-1- | |
dc.subject | transmission | |
dc.subject | DNA proviral load | |
dc.title | Low DNA HTLV-2 proviral load among women in Sao Paulo city | |
dc.type | Artículos de revistas | |