dc.creatorARANTES-COSTA, Fernanda M.
dc.creatorLOPES, Fernanda D. T. Q. S.
dc.creatorTOLEDO, Alessandra C.
dc.creatorMAGLIARELLI-FILHO, Pedro A.
dc.creatorMORIYA, Henrique T.
dc.creatorCARVALHO-OLIVEIRA, Regiane
dc.creatorMAUAD, Thais
dc.creatorSALDIVA, Paulo H. N.
dc.creatorMARTINS, Milton A.
dc.date.accessioned2012-10-19T18:26:46Z
dc.date.accessioned2018-07-04T15:13:29Z
dc.date.available2012-10-19T18:26:46Z
dc.date.available2018-07-04T15:13:29Z
dc.date.created2012-10-19T18:26:46Z
dc.date.issued2008
dc.identifierTOXICOLOGIC PATHOLOGY, v.36, n.5, p.680-686, 2008
dc.identifier0192-6233
dc.identifierhttp://producao.usp.br/handle/BDPI/23512
dc.identifier10.1177/0192623308317427
dc.identifierhttp://dx.doi.org/10.1177/0192623308317427
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1620242
dc.description.abstracttransition metals, which are involved in the pathological effects of PM. The objective of this study was to investigate the effects of intranasal administration of ROFA on pulmonary inflammation, pulmonary responsiveness, and excess mucus production in a mouse model of chronic pulmonary allergic inflammation. BALB/c mice received intraperitoneal injections of ovalbumin (OVA) solution (days 1 and 14). OVA challenges were performed on days 22, 24, 26, and 28. After the challenge, mice were intranasally instilled with ROFA. After forty-eight hours, pulmonary responsiveness was performed. Mice were sacrificed, and lungs were removed for morphometric analysis. OVA-exposed mice presented eosinophilia in the bronchovascular space (p < .001), increased pulmonary responsiveness (p < .001), and epithelial remodeling (p = .003). ROFA instillation increased pulmonary responsiveness (p = .004) and decreased the area of ciliated cells in the airway epithelium (p = .006). The combined ROFA instillation and OVA exposure induced a further increase in values of pulmonary responsiveness (p = .043) and a decrease in the number of ciliated cells in the airway epithelium (p = .017). PM exposure results in pulmonary effects that are more intense in mice with chronic allergic pulmonary inflammation.
dc.languageeng
dc.publisherSAGE PUBLICATIONS INC
dc.relationToxicologic Pathology
dc.rightsCopyright SAGE PUBLICATIONS INC
dc.rightsrestrictedAccess
dc.subjectasthma
dc.subjectexperimental asthma models
dc.subjectROFA
dc.subjectparticulate matter
dc.subjectepithelial remodeling
dc.subjecteosinophils
dc.subjectpulmonary responsiveness
dc.titleEffects of Residual Oil Fly Ash (ROFA) in Mice with Chronic Allergic Pulmonary Inflammation
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución