Artículos de revistas
Chemokine Receptors Expression on T Cells and Response to HAART Among Chronic HIV-1-Infected Subjects
Fecha
2008Registro en:
Current HIV Research, v.6, n.6, p.539-543, 2008
1570-162X
10.2174/157016208786501436
Autor
BRITO, Adriana
RIGATO, Paula O.
ALMEIDA, Alexandre
FERNANDES, Simone S.
GONSALEZ, Claudio R.
FONSECA, Luiz A. M.
DUARTE, Alberto J. S.
CASSEB, Jorge
Institución
Resumen
Chemokines receptors are used by HIV-1 for entry into CD4(+) T cells. The chemokines are capable of inhibiting HIV replication. This study determined the CCR5 and CXCR4 expression on T cells in HIV-1-infected patients treated with HAART. The successfully treated group ( plasma viral load 400 copies/mL), when compared with the failure group ( plasma viral load >400 copies/mL), had higher median CD4+ T cells count ( 583 and 245 cells/mm(3); respectively, p<0.0001). The failure patients had higher numbers and intensity of CCR5 and CXCR4-expressing T cells. Successfully treated patients were able to normalize the co-receptors expression-over on T cells. The viremic group showed higher CCR5 expression on CD4+ T cells and lower number of cells; CCR5 expression was normalized in the aviremic group; the naive group showed lower CCR5 expression and higher numbers of CD4 T cells; all groups showed normal CXCR4 expression compared to healthy controls. These findings may have clinical implications, since down-regulation of these co-receptors could be an adjuvant strategy for anti-HIV treatment.