dc.creatorFARIA, Maria Estela Justamante de
dc.creatorCARVALHO, Luciani R.
dc.creatorROSSETTO, Shirley M.
dc.creatorAMARAL, Terezinha Sampaio
dc.creatorBERGER, Karina
dc.creatorARNHOLD, Ivo Jorge Prado
dc.creatorMENDONCA, Berenice Bilharinho
dc.date.accessioned2012-10-19T18:26:00Z
dc.date.accessioned2018-07-04T15:12:54Z
dc.date.available2012-10-19T18:26:00Z
dc.date.available2018-07-04T15:12:54Z
dc.date.created2012-10-19T18:26:00Z
dc.date.issued2009
dc.identifierHORMONE RESEARCH, v.71, n.3, p.173-177, 2009
dc.identifier0301-0163
dc.identifierhttp://producao.usp.br/handle/BDPI/23386
dc.identifier10.1159/000197875
dc.identifierhttp://dx.doi.org/10.1159/000197875
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1620116
dc.description.abstractBackground/Aims: There are many controversies regarding side effects on craniofacial and extremity growth due to growth hormone ( GH) treatment. Our aim was to estimate GH action on craniofacial development and extremity growth in GH-deficient patients. Methods: Twenty patients with GH deficiency with a chronological age ranging from 4.6 to 24.3 years (bone age from 1.5 to 13 years) were divided in 2 groups: group 1 (n = 6), naive to GH treatment, and group 2 (n = 14), ongoing GH treatment for 2-11 years. GH doses (0.1 -0.15 U/kg/day) were adjusted to maintain insulin-like growth factor 1 and insulin-like growth factor binding protein 3 levels within the normal range. Anthropometric measurements, cephalometric analyses and facial photographs to verify profile and harmony were performed annually for at least 3 years. Results: Two patients with a disharmonious profile due to mandibular growth attained harmony, and none of them developed facial disharmony. Increased hand or foot size (>P97) was observed in 2 female patients and in 4 patients (1 female), respectively, both not correlated with GH treatment duration and increased levels of insulin-like growth factor 1. Conclusions: GH treatment with standard doses in GH-deficient patients can improve the facial profile in retrognathic patients and does not lead to facial disharmony although extremity growth, mainly involving the feet, can occur. Copyright (C) 2009 S. Karger AG, Basel
dc.languageeng
dc.publisherKARGER
dc.relationHormone Research
dc.rightsCopyright KARGER
dc.rightsrestrictedAccess
dc.subjectSkull growth and development
dc.subjectGrowth hormone deficiency
dc.subjectHypopituitarism
dc.subjectGrowth hormone therapeutic use
dc.titleAnalysis of Craniofacial and Extremity Growth in Patients with Growth Hormone Deficiency during Growth Hormone Therapy
dc.typeArtículos de revistas


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