dc.creator | NDHLOVU, L. C. | |
dc.creator | SNYDER-CAPPIONE, J. E. | |
dc.creator | CARVALHO, K. I. | |
dc.creator | LEAL, F. E. | |
dc.creator | LOO, C. P. | |
dc.creator | BRUNO, F. R. | |
dc.creator | JHA, A. R. | |
dc.creator | DEVITA, D. | |
dc.creator | HASENKRUG, A. M. | |
dc.creator | BARBOSA, H. M. R. | |
dc.creator | SEGURADO, A. C. | |
dc.creator | NIXON, D. F. | |
dc.creator | MURPHY, E. L. | |
dc.creator | KALLAS, E. G. | |
dc.date.accessioned | 2012-10-19T18:24:48Z | |
dc.date.accessioned | 2018-07-04T15:12:01Z | |
dc.date.available | 2012-10-19T18:24:48Z | |
dc.date.available | 2018-07-04T15:12:01Z | |
dc.date.created | 2012-10-19T18:24:48Z | |
dc.date.issued | 2009 | |
dc.identifier | CLINICAL AND EXPERIMENTAL IMMUNOLOGY, v.158, n.3, p.294-299, 2009 | |
dc.identifier | 0009-9104 | |
dc.identifier | http://producao.usp.br/handle/BDPI/23185 | |
dc.identifier | 10.1111/j.1365-2249.2009.04019.x | |
dc.identifier | http://dx.doi.org/10.1111/j.1365-2249.2009.04019.x | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1619915 | |
dc.description.abstract | Human T lymphotropic virus type 1 (HTLV-1) infects 10-20 million people worldwide. The majority of infected individuals are asymptomatic; however, approximately 3% develop the debilitating neurological disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). There is also currently no cure, vaccine or effective therapy for HTLV-1 infection, and the mechanisms for progression to HAM/TSP remain unclear. NK T cells are an immunoregulatory T cell subset whose frequencies and effector functions are associated critically with immunity against infectious diseases. We hypothesized that NK T cells are associated with HAM/TSP progression. We measured NK T cell frequencies and absolute numbers in individuals with HAM/TSP infection from two cohorts on two continents: Sao Paulo, Brazil and San Francisco, CA, USA, and found significantly lower levels when compared with healthy subjects and/or asymptomatic carriers. Also, the circulating NK T cell compartment in HAM/TSP subjects is comprised of significantly more CD4(+) and fewer CD8(+) cells than healthy controls. These findings suggest that lower numbers of circulating NK T cells and enrichment of the CD4(+) NK T subset are associated with HTLV-1 disease progression. | |
dc.language | eng | |
dc.publisher | WILEY-BLACKWELL PUBLISHING, INC | |
dc.relation | Clinical and Experimental Immunology | |
dc.rights | Copyright WILEY-BLACKWELL PUBLISHING, INC | |
dc.rights | restrictedAccess | |
dc.subject | CD8 | |
dc.subject | HTLV-1 infection | |
dc.subject | innate immunity | |
dc.subject | NK T cells | |
dc.subject | CD4 | |
dc.title | Lower numbers of circulating natural killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological disease | |
dc.type | Artículos de revistas | |