Artículos de revistas
Reticular angiomatoid ""malignant"" fibrous histiocytoma-a case report with cytogenetics and molecular genetic analyses
Fecha
2011Registro en:
HUMAN PATHOLOGY, v.42, n.9, p.1359-1363, 2011
0046-8177
10.1016/j.humpath.2010.12.003
Autor
MOURA, Rafael D.
WANG, Xiaoke
LONZO, Melissa L.
ERICKSON-JOHNSON, Michele R.
GARCIA, Joaquin J.
OLIVEIRA, Andre M.
Institución
Resumen
Angiomatoid ""malignant"" fibrous histiocytoma is a rare sarcoma of low malignant potential that occurs most commonly in the extremities of children and young adults. Herein, we present a case of angiomatoid malignant fibrous histiocytoma with unusual histologic features arising in the mediastinum of an 80-year-old man. The tumor exhibited a reticular growth pattern and myxoid stroma. The tumor cells expressed epithelial membrane antigen and desmin. Cytogenetic analysis revealed the translocation t(2;22)(q33;q12). Molecular genetic analysis confirmed the rearrangement of the EWSR1 locus and the presence of the EWSR1/CREB1 fusion. This report expands the clinicopathologic spectrum of angiomatoid malignant fibrous histiocytoma and underscores the value of integrating morphologic, immunophenotypic, and molecular findings in the identification of its unusual morphologic variants. (C) 2011 Elsevier Inc. All rights reserved.