Artículos de revistas
Immunohistochemical study of Langerhans cells in cutaneous lesions of the Jorge Lobo`s disease
Fecha
2010Registro en:
ACTA TROPICA, v.114, n.1, p.59-62, 2010
0001-706X
10.1016/j.actatropica.2009.12.005
Autor
QUARESMA, Juarez Antonio Simoes
UNGER, Debora
PAGLIARI, Carla
SOTTO, Mirian Nacagami
DUARTE, Maria Irma Seixas
BRITO, Arival Cardoso de
Institución
Resumen
Jorge Lobo`s disease is a chronic infection caused by the fungus Lacazia loboi endemic in South America. The infection is characterized by the appearance of parakeloidal, ulcerated or verrucous nodular or plaque-like cutaneous lesions. The histopathological aspect is characterized by poorly organized granulomas with histiocytes and multinucleated giant cells. Little is known about local immune response in lobomycosis skin lesions. Thirty-three skin biopsies from patients with Jorge Lobo`s disease were selected from Ambulatory of Dermatology, UFPA. The control group was constituted by ten biopsies from normal skin. Langerhans cells were identified by immunohistochemistry using anti-CD1a antibody (Serotec). The number of positive cells was statistically analyzed. Langerhans cells were visualized along the epidermis in biopsies from Jorge Lobo`s disease and the morphology and the number of Langerhans cells did not differ from normal skin (p > 0.05). In Jorge Lobo`s disease, this cell population probably presents some escape mechanism of the local immune system to evade the antigen presentation by those cells. (C) 2010 Published by Elsevier B.V.