dc.creator | ABREU, Soraia C. | |
dc.creator | ANTUNES, Mariana A. | |
dc.creator | MARON-GUTIERREZ, Tatiana | |
dc.creator | CRUZ, Fernanda F. | |
dc.creator | CARMO, Luana G. R. R. | |
dc.creator | ORNELLAS, Debora S. | |
dc.creator | CARREIRA JUNIOR, Humberto | |
dc.creator | ABISABER, Alexandre M. | |
dc.creator | PARRA, Edwin R. | |
dc.creator | CAPELOZZI, Vera L. | |
dc.creator | MORALES, Marcelo M. | |
dc.creator | ROCCO, Patricia R. M. | |
dc.date.accessioned | 2012-10-19T17:53:13Z | |
dc.date.accessioned | 2018-07-04T15:10:03Z | |
dc.date.available | 2012-10-19T17:53:13Z | |
dc.date.available | 2018-07-04T15:10:03Z | |
dc.date.created | 2012-10-19T17:53:13Z | |
dc.date.issued | 2011 | |
dc.identifier | RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, v.175, n.1, p.153-163, 2011 | |
dc.identifier | 1569-9048 | |
dc.identifier | http://producao.usp.br/handle/BDPI/22741 | |
dc.identifier | 10.1016/j.resp.2010.10.006 | |
dc.identifier | http://dx.doi.org/10.1016/j.resp.2010.10.006 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1619472 | |
dc.description.abstract | We hypothesized that bone marrow-derived mononuclear cells (BMDMC) would attenuate the remodeling process in a chronic allergic inflammation model. C57BL/6 mice were assigned to two groups. In OVA, mice were sensitized and repeatedly challenged with ovalbumin. Control mice (C) received saline under the same protocol. C and OVA were further randomized to receive BMDMC (2 x 10(6)) or saline intravenously 24 h before the first challenge. BMDMC therapy reduced eosinophil infiltration, smooth muscle-specific actin expression, subepithelial fibrosis, and myocyte hypertrophy and hyperplasia, thus causing a decrease in airway hyperresponsiveness and lung mechanical parameters. BMDMC from green fluorescent protein (GFP)-transgenic mice transplanted into GFP-negative mice yielded lower engraftment in OVA. BMDMC increased insulin-like growth factor expression, but reduced interleukin-5, transforming growth factor-beta, platelet-derived growth factor, and vascular endothelial growth factor mRNA expression. In conclusion, in the present chronic allergic inflammation model, BMDMC therapy was an effective pre-treatment protocol that potentiated airway epithelial cell repair and prevented inflammatory and remodeling processes. (C) 2010 Elsevier B.V. All rights reserved. | |
dc.language | eng | |
dc.publisher | ELSEVIER SCIENCE BV | |
dc.relation | Respiratory Physiology & Neurobiology | |
dc.rights | Copyright ELSEVIER SCIENCE BV | |
dc.rights | restrictedAccess | |
dc.subject | Inflammation | |
dc.subject | Collagen fiber | |
dc.subject | Lung mechanics | |
dc.subject | Stem cells | |
dc.subject | Asthma | |
dc.title | Effects of bone marrow-derived mononuclear cells on airway and lung parenchyma remodeling in a murine model of chronic allergic inflammation | |
dc.type | Artículos de revistas | |