dc.creatorANDRADE, G. B.
dc.creatorLADEIRA, S. L.
dc.creatorBATTLEHNER, C. N.
dc.creatorSALDIVA, P. H. N.
dc.creatorCALDINI, E. G.
dc.date.accessioned2012-10-19T17:53:03Z
dc.date.accessioned2018-07-04T15:09:57Z
dc.date.available2012-10-19T17:53:03Z
dc.date.available2018-07-04T15:09:57Z
dc.date.created2012-10-19T17:53:03Z
dc.date.issued2008
dc.identifierVETERINARY RESEARCH COMMUNICATIONS, v.32, n.1, p.65-74, 2008
dc.identifier0165-7380
dc.identifierhttp://producao.usp.br/handle/BDPI/22719
dc.identifier10.1007/s11259-007-9003-0
dc.identifierhttp://dx.doi.org/10.1007/s11259-007-9003-0
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1619450
dc.description.abstractThis work aimed to investigate some aspects related to the pathogenicity of Lechiguana, a bovine fibroproliferative lesion characterized by rapid collagen accumulation. Light and transmission electron microscopy and in situ hybridization studies were performed in order to elucidate the fibrogenic activity of this lesion. The characterization of fibroblastic plasticity in the lesion was done by immunohistochemical study for alpha-smooth-muscle cell actin. The ovoid-shaped cells presented positive reaction for alpha-smooth-muscle cell actin in their cytoplasm and, at the electron-microscopic level demonstrated basal lamina-like material adjacent to the external surface and collagen fibrils that corresponded to a cell population phenotypically similar to the myofibroblast. We also investigated alpha 1 collagen type I mRNA at different times of evolution of Lechiguana lesions, using isotopic and non-isotopic in situ hybridization. The results strongly suggest the involvement of a myofibroblast-like cell population that expresses mRNA for type I collagen and is probably associated with the increase of collagen deposition.
dc.languageeng
dc.publisherSPRINGER
dc.relationVeterinary Research Communications
dc.rightsCopyright SPRINGER
dc.rightsrestrictedAccess
dc.subjectlechiguana
dc.subjectmyofibroblast
dc.subjectfibrosis
dc.subjectcollagen
dc.subjectin situ hybridization
dc.subjectlmmunohistochemistry
dc.subjectalpha-SM actin
dc.titleMolecular and ultrastructural studies of the fibrotic lesions of bovine focal proliferative fibrogranulomatous panniculitis (Lechiguana)
dc.typeArtículos de revistas


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