Increased Brain Membrane Fluidity in Schizophrenia

dc.creatorECKERT, G. P.
dc.creatorSCHAEFFER, E. L.
dc.creatorSCHMITT, A.
dc.creatorMARAS, A.
dc.creatorGATTAZ, W. F.
dc.date.accessioned2012-10-19T17:35:25Z
dc.date.accessioned2018-07-04T15:09:18Z
dc.date.available2012-10-19T17:35:25Z
dc.date.available2018-07-04T15:09:18Z
dc.date.created2012-10-19T17:35:25Z
dc.date.issued2011
dc.identifierPHARMACOPSYCHIATRY, v.44, n.4, p.161-163, 2011
dc.identifier0176-3679
dc.identifierhttp://producao.usp.br/handle/BDPI/22542
dc.identifier10.1055/s-0031-1279731
dc.identifierhttp://dx.doi.org/10.1055/s-0031-1279731
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1619314
dc.description.abstractRecent findings showing significant correlations between phospholipase A2 (PLA2) activity and structural changes in schizophrenic brains contribute to the membrane hypothesis of schizophrenia, which was hampered because a clean functional link between elevated PLA2 activity and brain structure was missing (Neuroimage, 2010; 52: 1314-1327). We measured membrane fluidity parameters and found that brain membranes isolated from the prefrontal cortex of schizophrenic patients showed significantly increased flexibility of fatty acid chains. Our findings support a possible link between elevated PLA2 activity in cortical areas of schizophrenic patients and subsequent alterations of the biophysical parameters of neuronal membranes leading to structural changes in these areas.
dc.languageeng
dc.publisherGEORG THIEME VERLAG KG
dc.relationPharmacopsychiatry
dc.rightsCopyright GEORG THIEME VERLAG KG
dc.rightsclosedAccess
dc.subjectschizophrenia
dc.subjectmembrane
dc.subjectPLA2
dc.titleIncreased Brain Membrane Fluidity in Schizophrenia
dc.typeArtículos de revistas


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