Immunogenicity of 23-valent pneumococcal polysaccharide vaccine in HIV-infected pregnant women and kinetics of passively acquired antibodies in young infants

dc.creatorALMEIDA, Volia De Carvalho
dc.creatorMUSSI-PINHATA, Marisa Marcia
dc.creatorSOUZA, Cleonice Barbosa Sandoval De
dc.creatorKUBO, Christina Arslanian
dc.creatorMARTINEZ, Edson Zangiacomi
dc.creatorCARNEIRO-SAMPAIO, Magda Maria
dc.creatorDUARTE, Geraldo
dc.date.accessioned2012-10-19T17:34:15Z
dc.date.accessioned2018-07-04T15:08:58Z
dc.date.available2012-10-19T17:34:15Z
dc.date.available2018-07-04T15:08:58Z
dc.date.created2012-10-19T17:34:15Z
dc.date.issued2009
dc.identifierVACCINE, v.27, n.29, p.3856-3861, 2009
dc.identifier0264-410X
dc.identifierhttp://producao.usp.br/handle/BDPI/22466
dc.identifier10.1016/j.vaccine.2009.04.018
dc.identifierhttp://dx.doi.org/10.1016/j.vaccine.2009.04.018
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1619238
dc.description.abstractWhether gestational immunization of HIV-infected mothers with the 23-valent pneumococcal polysaccharide vaccine (PPV) confers maternal and infant early life, passive protection is not known. We evaluated safety, immunogenicity and placental transfer of antibodies in 44 HIV-infected women. Pneumococcal IgG antibodies against serotypes 1, 3, 5, 613, 9V, and 14 were measured in mothers (pre-vaccination and at delivery), and infants (at birth, 1, 2, 3, and 6 months). PPV was safe and immunogenic in mothers. Newborns received 46-72% of maternal antibody titers. Overall, infants had antibody levels lower than protective by 2 months of age. Alternative pneumococcal vaccination of HIV-infected pregnant women should be explored with the aim of prolonging passive protection in their infants. (C) 2009 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherELSEVIER SCI LTD
dc.relationVaccine
dc.rightsCopyright ELSEVIER SCI LTD
dc.rightsrestrictedAccess
dc.subjectPneumococcal polysaccharide vaccine
dc.subjectHIV-infected pregnant woman
dc.subjectPassively acquired pneumococcal antibodies
dc.titleImmunogenicity of 23-valent pneumococcal polysaccharide vaccine in HIV-infected pregnant women and kinetics of passively acquired antibodies in young infants
dc.typeArtículos de revistas


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