dc.creator | ALMEIDA, Volia De Carvalho | |
dc.creator | MUSSI-PINHATA, Marisa Marcia | |
dc.creator | SOUZA, Cleonice Barbosa Sandoval De | |
dc.creator | KUBO, Christina Arslanian | |
dc.creator | MARTINEZ, Edson Zangiacomi | |
dc.creator | CARNEIRO-SAMPAIO, Magda Maria | |
dc.creator | DUARTE, Geraldo | |
dc.date.accessioned | 2012-10-19T17:34:15Z | |
dc.date.accessioned | 2018-07-04T15:08:58Z | |
dc.date.available | 2012-10-19T17:34:15Z | |
dc.date.available | 2018-07-04T15:08:58Z | |
dc.date.created | 2012-10-19T17:34:15Z | |
dc.date.issued | 2009 | |
dc.identifier | VACCINE, v.27, n.29, p.3856-3861, 2009 | |
dc.identifier | 0264-410X | |
dc.identifier | http://producao.usp.br/handle/BDPI/22466 | |
dc.identifier | 10.1016/j.vaccine.2009.04.018 | |
dc.identifier | http://dx.doi.org/10.1016/j.vaccine.2009.04.018 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1619238 | |
dc.description.abstract | Whether gestational immunization of HIV-infected mothers with the 23-valent pneumococcal polysaccharide vaccine (PPV) confers maternal and infant early life, passive protection is not known. We evaluated safety, immunogenicity and placental transfer of antibodies in 44 HIV-infected women. Pneumococcal IgG antibodies against serotypes 1, 3, 5, 613, 9V, and 14 were measured in mothers (pre-vaccination and at delivery), and infants (at birth, 1, 2, 3, and 6 months). PPV was safe and immunogenic in mothers. Newborns received 46-72% of maternal antibody titers. Overall, infants had antibody levels lower than protective by 2 months of age. Alternative pneumococcal vaccination of HIV-infected pregnant women should be explored with the aim of prolonging passive protection in their infants. (C) 2009 Elsevier Ltd. All rights reserved. | |
dc.language | eng | |
dc.publisher | ELSEVIER SCI LTD | |
dc.relation | Vaccine | |
dc.rights | Copyright ELSEVIER SCI LTD | |
dc.rights | restrictedAccess | |
dc.subject | Pneumococcal polysaccharide vaccine | |
dc.subject | HIV-infected pregnant woman | |
dc.subject | Passively acquired pneumococcal antibodies | |
dc.title | Immunogenicity of 23-valent pneumococcal polysaccharide vaccine in HIV-infected pregnant women and kinetics of passively acquired antibodies in young infants | |
dc.type | Artículos de revistas | |