dc.creatorVENDRAME, Celia M. V.
dc.creatorSOUZA, Luana D.
dc.creatorCARVALHO, Marcia D. T.
dc.creatorSALGADO, Katia
dc.creatorCARVALHO, Edgar M.
dc.creatorGOTO, Hiro
dc.date.accessioned2012-10-19T17:32:28Z
dc.date.accessioned2018-07-04T15:08:41Z
dc.date.available2012-10-19T17:32:28Z
dc.date.available2018-07-04T15:08:41Z
dc.date.created2012-10-19T17:32:28Z
dc.date.issued2010
dc.identifierTRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, v.104, n.8, p.566-568, 2010
dc.identifier0035-9203
dc.identifierhttp://producao.usp.br/handle/BDPI/22409
dc.identifier10.1016/j.trstmh.2010.03.007
dc.identifierhttp://dx.doi.org/10.1016/j.trstmh.2010.03.007
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1619181
dc.description.abstractArginase activity has been related to leishmaniasis development, thus we studied the constitutive and insulin-like growth factor (IGF) I-induced arginase activity of Leishmania (Viannia) braziliensis isolates from patients with different clinical forms of American tegumentary leishmaniasis (ATL). Isolates from mucosal leishmaniasis presented higher basal levels of arginase activity than isolates from other clinical forms of ATL. Isolates from disseminated leishmaniasis that present mucosal lesion in some cases reached the arginase activity similar to that of isolates from mucosal leishmaniasis upon IGF-I stimulation. Differences in arginase activity may influence disease outcomes such as evolution to mucosal lesion in patients with L (V.) braziliensis infection. (C) 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherELSEVIER SCIENCE INC
dc.relationTransactions of the Royal Society of Tropical Medicine and Hygiene
dc.rightsCopyright ELSEVIER SCIENCE INC
dc.rightsrestrictedAccess
dc.subjectLeishmania braziliensis
dc.subjectCutaneous leishmaniasis
dc.subjectMucosal leishmaniasis
dc.subjectDisseminated leishmaniasis
dc.subjectArginase
dc.subjectInsulin-like growth factor I
dc.titleInsulin-like growth factor-I induced and constitutive arginase activity differs among isolates of Leishmania derived from patients with diverse clinical forms of Leishmania braziliensis infection
dc.typeArtículos de revistas


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