Characterization of Leishmania (Leishmania) amazonensis promastigotes resistant to pentamidine

dc.creatorCOELHO, Adriano C.
dc.creatorGENTIL, Luciana G.
dc.creatorSILVEIRA, Jose Franco da
dc.creatorCOTRIM, Paulo C.
dc.date.accessioned2012-10-19T17:29:31Z
dc.date.accessioned2018-07-04T15:07:39Z
dc.date.available2012-10-19T17:29:31Z
dc.date.available2018-07-04T15:07:39Z
dc.date.created2012-10-19T17:29:31Z
dc.date.issued2008
dc.identifierEXPERIMENTAL PARASITOLOGY, v.120, n.1, p.98-102, 2008
dc.identifier0014-4894
dc.identifierhttp://producao.usp.br/handle/BDPI/22172
dc.identifier10.1016/j.exppara.2008.03.018
dc.identifierhttp://dx.doi.org/10.1016/j.exppara.2008.03.018
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1618945
dc.description.abstractPentamidine is a second-line agent used in the treatment of leishmaniasis and its mode of action and mechanism of resistance is not well understood. It was previously demonstrated that transfection of promastigotes and amastigotes with the ABC transporter PRP1 gene confers resistance to pentamidine. To further clarify this point, we generated Leishmania amazonensis mutants resistant to pentamidine. Our results indicated that this ABC transporter is not associated with pentamidine resistance in lines generated by drug pressure through amplification or overexpression mechanisms of PRP1 gene. (C) 2008 Elsevier Inc. All rights reserved.
dc.languageeng
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relationExperimental Parasitology
dc.rightsCopyright ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.rightsrestrictedAccess
dc.subjectLeishmania
dc.subjectpentamidine
dc.subjectdrug resistance
dc.subjectABC transporter
dc.titleCharacterization of Leishmania (Leishmania) amazonensis promastigotes resistant to pentamidine
dc.typeArtículos de revistas


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