dc.creatorVIEIRA, Rodolfo P.
dc.creatorANDRADE, Vanessa F. de
dc.creatorDUARTE, Anna Cecilia S.
dc.creatorSANTOS, Angela B. G. dos
dc.creatorMAUAD, Thais
dc.creatorMARTINS, Milton A.
dc.creatorDOLHNIKOFF, Marisa
dc.creatorCARVALHO, Celso R. F.
dc.date.accessioned2012-10-19T17:24:54Z
dc.date.accessioned2018-07-04T15:07:06Z
dc.date.available2012-10-19T17:24:54Z
dc.date.available2018-07-04T15:07:06Z
dc.date.created2012-10-19T17:24:54Z
dc.date.issued2008
dc.identifierAMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, v.295, n.4, p.L670-L679, 2008
dc.identifier1040-0605
dc.identifierhttp://producao.usp.br/handle/BDPI/22051
dc.identifier10.1152/ajplung.00465.2007
dc.identifierhttp://dx.doi.org/10.1152/ajplung.00465.2007
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1618824
dc.description.abstractVieira RP, de Andrade VF, Duarte AC, dos Santos AB, Mauad T, Martins MA, Dolhnikoff M, Carvalho CR. Aerobic conditioning and allergic pulmonary inflammation in mice. II. Effects on lung vascular and parenchymal inflammation and remodeling. Am J Physiol Lung Cell Mol Physiol 295: L670-L679, 2008. First published August 29, 2008; doi: 10.1152/ajplung.00465.2007.-Recent evidence suggests that asthma leads to inflammation and remodeling not only in the airways but also in pulmonary vessels and parenchyma. In addition, some studies demonstrated that aerobic training decreases chronic allergic inflammation in the airways; however, its effects on the pulmonary vessels and parenchyma have not been previously evaluated. Our objective was to test the hypothesis that aerobic conditioning reduces inflammation and remodeling in pulmonary vessels and parenchyma in a model of chronic allergic lung inflammation. Balb/c mice were sensitized at days 0, 14, 28, and 42 and challenged with ovalbumin ( OVA) from day 21 to day 50. Aerobic training started on day 21 and continued until day 50. Pulmonary vessel and parenchyma inflammation and remodeling were evaluated by quantitative analysis of eosinophils and mononuclear cells and by collagen and elastin contents and smooth muscle thickness. Immunohistochemistry was performed to quantify the density of positive cells to interleukin (IL)-2, IL-4, IL-5, interferon-gamma, IL-10, monocyte chemotatic protein (MCP)-1, nuclear factor (NF)-kappa B p65, and insulin-like growth factor (IGF)-I. OVA exposure induced pulmonary blood vessels and parenchyma inflammation as well as increased expression of IL-4, IL-5, MCP-1, NF-kappa B p65, and IGF-I by inflammatory cells were reduced by aerobic conditioning. OVA exposure also induced an increase in smooth muscle thickness and elastic and collagen contents in pulmonary vessels, which were reduced by aerobic conditioning. Aerobic conditioning increased the expression of IL-10 in sensitized mice. We conclude that aerobic conditioning decreases pulmonary vascular and parenchymal inflammation and remodeling in this experimental model of chronic allergic lung inflammation in mice.
dc.languageeng
dc.publisherAMER PHYSIOLOGICAL SOC
dc.relationAmerican Journal of Physiology-lung Cellular and Molecular Physiology
dc.rightsCopyright AMER PHYSIOLOGICAL SOC
dc.rightsrestrictedAccess
dc.subjectasthma
dc.subjectaerobic training
dc.subjectcytokines
dc.subjectpulmonary inflammation
dc.subjectpulmonary remodeling
dc.titleAerobic conditioning and allergic pulmonary inflammation in mice. II. Effects on lung vascular and parenchymal inflammation and remodeling
dc.typeArtículos de revistas


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