dc.creatorSETTA, Jose Henrique
dc.creatorNEDER, Jose Alberto
dc.creatorBAGATIN, Ericson
dc.creatorTERRA-FILHO, Mario
dc.creatorNAPOLIS, Lara Maris
dc.creatorCORSO, Simone Dal
dc.creatorAMORIN, Maria Marta Ferreira
dc.creatorRODRIGUES, Reynaldo Tavares
dc.creatorFERNANDES, Ana Luisa Godoy
dc.creatorNERY, Luiz Eduardo
dc.date.accessioned2012-10-19T17:17:06Z
dc.date.accessioned2018-07-04T15:05:49Z
dc.date.available2012-10-19T17:17:06Z
dc.date.available2018-07-04T15:05:49Z
dc.date.created2012-10-19T17:17:06Z
dc.date.issued2008
dc.identifierAMERICAN JOURNAL OF INDUSTRIAL MEDICINE, v.51, n.3, p.186-194, 2008
dc.identifier0271-3586
dc.identifierhttp://producao.usp.br/handle/BDPI/21759
dc.identifier10.1002/ajim.20546
dc.identifierhttp://dx.doi.org/10.1002/ajim.20546
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1618533
dc.description.abstractBackground Asbestosis is associated with lung cellular and immunological abnormalities. Induced sputum cytology and local and systemic markers of inflammation may be helpful to characterize disease status and progression in these patients. Methods Thirty-nine ex-workers with asbestosis on high-resolution CT (HRCT) and 21 non-exposed controls were evaluated. Sputum cytology and IL-8 in serum and sputum were related to lung function impairment. Results Subjects with asbestosis had reduced sputum cellularity but higher macrophagel neutrophil ratio and % macrophage as compared with controls. Sputum and serum IL-8 were also higher in patients with asbestosis (P < 0.05). In addition, evidence of lung architectural distorption on HRCT was associated with increased levels of serum IL-8. Interestingly, absolute macrophage number was negatively correlated with total lung capacity (r = -0.40; P = 0.04) and serum IL-8 to lung diffiusing capacity (r = -0.45; P = 0.01). Conclusions Occupationally exposed subjects with asbestosis on HRCT have cytologic abnormalities in induced sputum and increased local and systemic pro-inflammatory status which are correlated to functional impairment.
dc.languageeng
dc.publisherWILEY-LISS
dc.relationAmerican Journal of Industrial Medicine
dc.rightsCopyright WILEY-LISS
dc.rightsrestrictedAccess
dc.subjectasbestosis
dc.subjectinflammation
dc.subjectpulmonary function
dc.subjectinduced sputum
dc.subjectcytokines
dc.titleRelationship between induced sputum cytology and inflammatory status with lung structural and functional abnormalities in asbestosis
dc.typeArtículos de revistas


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