dc.creatorCARVALHO, J. F.
dc.creatorPEREIRA, R. M. R.
dc.creatorSHOENFELD, Y.
dc.date.accessioned2012-10-19T17:09:17Z
dc.date.accessioned2018-07-04T15:05:48Z
dc.date.available2012-10-19T17:09:17Z
dc.date.available2018-07-04T15:05:48Z
dc.date.created2012-10-19T17:09:17Z
dc.date.issued2009
dc.identifierLUPUS, v.18, n.13, p.1209-1212, 2009
dc.identifier0961-2033
dc.identifierhttp://producao.usp.br/handle/BDPI/21754
dc.identifier10.1177/0961203309345725
dc.identifierhttp://dx.doi.org/10.1177/0961203309345725
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1618528
dc.description.abstractAtherosclerosis is an inflammatory disease, leading to the formation of pro-inflammatory and pro-oxidative lipids that generate an immune response. Several antigens have been shown to activate the immune response and affect the development of atherogenesis. Systemic lupus erythematosus is an autoimmune and inflammatory disease strongly associated with premature development of atherosclerotic plaques. Modulation of the immune system could represent a useful approach to prevent and/or treat atherosclerosis. A vaccination-based approach might be a useful, effective tool in the modern arsenal of cardiovascular therapies and could be used on a large scale at a low cost. In non-systemic lupus erythematosus populations, vaccines against oxidized low-density lipoprotein, beta-2-glycoprotein I, heat shock proteins, lipoproteins, cholesterol, molecules involved in cholesterol metabolism, and other molecules (CD99, vascular endothelial growth factor-receptor, and interleukin-2) have been tested, with promising results. However, there are no studies of vaccination against atherosclerosis in systemic lupus erythematosus. Lupus (2009) 18, 1209-1212.
dc.languageeng
dc.publisherSAGE PUBLICATIONS LTD
dc.relationLupus
dc.rightsCopyright SAGE PUBLICATIONS LTD
dc.rightsrestrictedAccess
dc.subjectsystemic lupus erythematosus
dc.subjectatherosclerosis
dc.subjectvaccination
dc.subjectautoimmunity
dc.subjectautoimmune diseases
dc.titleVaccination, atherosclerosis and systemic lupus erythematosus
dc.typeArtículos de revistas


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