dc.creatorPEREIRA, Ivanio Alves
dc.creatorLAURINDO, Ieda M. M.
dc.creatorZIMMERMANN, Adriana F.
dc.creatorCASTRO, Glaucio R. Werner
dc.creatorMELLO, Filipe
dc.creatorBORBA, Eduardo Ferreira
dc.date.accessioned2012-10-19T17:08:25Z
dc.date.accessioned2018-07-04T15:05:13Z
dc.date.available2012-10-19T17:08:25Z
dc.date.available2018-07-04T15:05:13Z
dc.date.created2012-10-19T17:08:25Z
dc.date.issued2009
dc.identifierACTA REUMATOLOGICA PORTUGUESA, v.34, n.1, p.58-64, 2009
dc.identifier0303-464X
dc.identifierhttp://producao.usp.br/handle/BDPI/21617
dc.identifierhttp://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000264981400006&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1618391
dc.description.abstractBackground: Although inflammation has a defined role in the pathogenesis of atherosclerosis, the link between rheumatoid arthritis (RA) parameters of disease activity and atherosclerotic findings are not defined. Objective: To investigate the association between subclinical carotid atherosclerosis and clinical/laboratorial parameters of RA systemic inflammatory activity. Methods: Seventy-one RA patients were consecutively selected and compared to 53 healthy controls. Smoking, diabetes and hypertension were excluded, as well as the use of statins or fibrates. B-mode carotid ultrasound was performed in all subjects. CRP, ESR and fibrinogen were determined in both groups. Clinical assessment of RA activity included DAS 28 and SDAI. Correlation between plaques and intima-media thickness (IMT) of common carotid arteries and inflammatory parameters was evaluated. Results: Carotid plaques were more prevalent in RA patients than in controls (14.1% vs. 1.9 %, p=0.02) and marginally increased IMT was observed (0.72 +/- 0.17 vs. 0.67 +/- 0.15mm, p=0.07). RA patients with plaques had older age (p=0.001) and increased IMT (p<0.001), but low SDAI (p=0.025) compared to those without plaques. RA patients with plaques had also longer disease duration, although this difference did not reach statistical significance (p=0.06). No significant correlations were found between IMT and ESR (p=0.80), CRP (p=0.75), fibrinogen (p=0.94), HAQ (p=0.89) and DAS 28 (p=0.13). Conclusions: Carotid atherosclerosis is more frequently detected in RA but its prevalence was not correlated with isolated inflammatory markers measurement or noncumulative activity scores. These findings reinforce the need to evaluate subclinical atherosclerosis in RA patients, and to find predictors of atherosclerotic lesions.
dc.languageeng
dc.publisherMEDFARMA-EDICOES MEDICAS, LDA
dc.relationActa Reumatologica Portuguesa
dc.rightsCopyright MEDFARMA-EDICOES MEDICAS, LDA
dc.rightsrestrictedAccess
dc.subjectRheumatoid Arthritis
dc.subjectAtherosclerosis
dc.subjectInflammation
dc.subjectC-reactive Protein
dc.titleSINGLE MEASUREMENTS OF C-REACTIVE PROTEIN AND DISEASE ACTIVITY SCORES ARE NOT PREDICTORS OF CAROTID ATHEROSCLEROSIS IN RHEUMATOID ARTHRITIS PATIENTS
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución