dc.creatorBAIA, Carlos Eduardo Sandoli
dc.creatorABDALA, Edson
dc.creatorMASSAROLLO, Paulo
dc.creatorBEDUSCHI, Thiago
dc.creatorPALMA, Thomson Marques
dc.creatorMIES, Sergio
dc.date.accessioned2012-10-19T17:03:12Z
dc.date.accessioned2018-07-04T15:04:53Z
dc.date.available2012-10-19T17:03:12Z
dc.date.available2018-07-04T15:04:53Z
dc.date.created2012-10-19T17:03:12Z
dc.date.issued2009
dc.identifierHEPATO-GASTROENTEROLOGY, v.56, n.94-95, p.1445-1451, 2009
dc.identifier0172-6390
dc.identifierhttp://producao.usp.br/handle/BDPI/21544
dc.identifierhttp://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000271716500037&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1618319
dc.description.abstractBackground/Aims: Cytokines have a significant role in the response to injury following liver transplantation, but the origin and course of such molecules are not completely known. The aim of this study was to evaluate the production and liver metabolism of the inflammatory cytokines interleukin (IL)-1 beta, IL-6, IL-8, interferon (IFN)-Y and tumor necrosis factor (TNF)-alpha in orthotopic liver transplantation (OLT), comparing the conventional and the piggyback methods. Methodology: We performed a study of 30 patients who underwent elective OLT and were randomized for the conventional or piggyback techniques at the beginning of the operation. The amount of cytokines and their hepatic metabolism were calculated based on plasma concentrations and vascular blood flow at 2, 5, 10, 15, 30, 60, 90, and 120 minutes after revascularization. Results: The amount of IL-1 beta in portal blood was higher in patients who underwent surgery using the conventional technique (estimate interest = 63,783.9 +/- 16,586.1 pg/min, versus 11,979.6 +/- 16,585.7 pg/min in the piggyback group, p=0.035). There were no significant differences between the two operative`s methods for IL-6, IL-8, IFN-Y and TNF-alpha production. The hepatic metabolism of cytokines was not different between groups. Although all the curves showed higher amounts of cytokines with the conventional technique, these were not statistically significant. Conclusion: The study shows the similarity between the two techniques concerning the stimuli for the production of inflammatory molecules.
dc.languageeng
dc.publisherH G E UPDATE MEDICAL PUBLISHING S A
dc.relationHepato-gastroenterology
dc.rightsCopyright H G E UPDATE MEDICAL PUBLISHING S A
dc.rightsclosedAccess
dc.subjectHemodynamic processes
dc.subjectLiver circulation
dc.subjectMetabolism
dc.subjectSplanchnic circulation
dc.subjectSurgical procedures
dc.titleInflammatory Cytokines during Liver Transplantation: Prospective Randomized Trial Comparing Conventional and Piggyback Techniques
dc.typeArtículos de revistas


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