dc.creator | AZEVEDO, Clerio F. | |
dc.creator | NIGRI, Marcelo | |
dc.creator | HIGUCHI, Maria L. | |
dc.creator | POMERANTZEFF, Pablo M. | |
dc.creator | SPINA, Guilherme S. | |
dc.creator | SAMPAIO, Roney O. | |
dc.creator | TARASOUTCHI, Flavio | |
dc.creator | GRINBERG, Max | |
dc.creator | ROCHITTE, Carlos Eduardo | |
dc.date.accessioned | 2012-10-19T16:59:22Z | |
dc.date.accessioned | 2018-07-04T15:03:04Z | |
dc.date.available | 2012-10-19T16:59:22Z | |
dc.date.available | 2018-07-04T15:03:04Z | |
dc.date.created | 2012-10-19T16:59:22Z | |
dc.date.issued | 2010 | |
dc.identifier | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, v.56, n.4, p.278-287, 2010 | |
dc.identifier | 0735-1097 | |
dc.identifier | http://producao.usp.br/handle/BDPI/21131 | |
dc.identifier | 10.1016/j.jacc.2009.12.074 | |
dc.identifier | http://dx.doi.org/10.1016/j.jacc.2009.12.074 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1617906 | |
dc.description.abstract | Objectives We sought to determine whether the quantitative assessment of myocardial fibrosis (MF), either by histopathology or by contrast-enhanced magnetic resonance imaging (ce-MRI), could help predict long-term survival after aortic valve replacement. Background Severe aortic valve disease is characterized by progressive accumulation of interstitial MF. Methods Fifty-four patients scheduled to undergo aortic valve replacement were examined by ce-MRI. Delayed-enhanced images were used for the quantitative assessment of MF. In addition, interstitial MF was quantified by histological analysis of myocardial samples obtained during open-heart surgery and stained with picrosirius red. The ce-MRI study was repeated 27 +/- 22 months after surgery to assess left ventricular functional improvement, and all patients were followed for 52 +/- 17 months to evaluate long-term survival. Results There was a good correlation between the amount of MF measured by histopathology and by ce-MRI (r = 0.69, p < 0.001). In addition, the amount of MF demonstrated a significant inverse correlation with the degree of left ventricular functional improvement after surgery (r = -0.42, p = 0.04 for histopathology; r = -0.47, p = 0.02 for ce-MRI). Kaplan-Meier analyses revealed that higher degrees of MF accumulation were associated with worse long-term survival (chi-square = 6.32, p = 0.01 for histopathology; chi-square = 5.85, p = 0.02 for ce-MRI). On multivariate Cox regression analyses, patient age and the amount of MF were found to be independent predictors of all-cause mortality. Conclusions The amount of MF, either by histopathology or by ce-MRI, is associated with the degree of left ventricular functional improvement and all-cause mortality late after aortic valve replacement in patients with severe aortic valve disease. (J Am Coll Cardiol 2010; 56: 278-87) (c) 2010 by the American College of Cardiology Foundation | |
dc.language | eng | |
dc.publisher | ELSEVIER SCIENCE INC | |
dc.relation | Journal of the American College of Cardiology | |
dc.rights | Copyright ELSEVIER SCIENCE INC | |
dc.rights | restrictedAccess | |
dc.subject | aortic valve disease | |
dc.subject | histopathology | |
dc.subject | magnetic resonance imaging | |
dc.subject | myocardial fibrosis | |
dc.subject | prognosis | |
dc.title | Prognostic Significance of Myocardial Fibrosis Quantification by Histopathology and Magnetic Resonance Imaging in Patients With Severe Aortic Valve Disease | |
dc.type | Artículos de revistas | |