dc.creatorSAWAN, Rosangela M. M.
dc.creatorLEITE, Giselle A. S.
dc.creatorSARAIVA, Maria C. P.
dc.creatorBARBOSA JR., Fernando
dc.creatorTANUS-SANTOS, Jose E.
dc.creatorGERLACH, Raquel F.
dc.date.accessioned2012-10-19T03:42:49Z
dc.date.accessioned2018-07-04T14:58:22Z
dc.date.available2012-10-19T03:42:49Z
dc.date.available2018-07-04T14:58:22Z
dc.date.created2012-10-19T03:42:49Z
dc.date.issued2010
dc.identifierTOXICOLOGY, v.271, n.1/Fev, p.21-26, 2010
dc.identifier0300-483X
dc.identifierhttp://producao.usp.br/handle/BDPI/20212
dc.identifier10.1016/j.tox.2010.02.002
dc.identifierhttp://dx.doi.org/10.1016/j.tox.2010.02.002
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1616996
dc.description.abstractHigher blood lead (BPb) levels have been reported in children living in communities that receive fluoride-treated water. Here, we examined whether fluoride co-administered with lead increases BPb and lead concentrations in calcified tissues in Wistar rats exposed to this metal from the beginning of gestation. We exposed female rats and their offspring to control water (Control Group), 100 mg/L of fluoride (F Group), 30 mg/L of lead (Pb Group), or 100 mg/L of fluoride and 30 mg/L of lead (F+ Pb Group) from 1 week prior to mating until offspring was 81 days old. Blood and calcified tissues (enamel, dentine, and bone) were harvested at day 81 for lead and fluoride analyses. Higher BPb concentrations were found in the F+ Pb Group compared with the Pb Group (76.7 +/- 11.0 mu g/dL vs. 22.6 +/- 8.5 mu g/dL, respectively: p <0.001). Two-to threefold higher lead concentrations were found in the calcified tissues in the F+ Pb Group compared with the Pb Group (all p <0.001). Fluoride concentrations were similar in the F and in the F+ Pb Groups. These findings show that fluoride consistently increases BPb and calcified tissues Pb concentrations in animals exposed to low levels of lead and suggest that a biological effect not yet recognized may underlie the epidemiological association between increased BPb lead levels in children living in water-fluoridated communities. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
dc.languageeng
dc.publisherELSEVIER IRELAND LTD
dc.relationToxicology
dc.rightsCopyright ELSEVIER IRELAND LTD
dc.rightsrestrictedAccess
dc.subjectFluoride
dc.subjectLead
dc.subjectWhole blood lead
dc.subjectBone
dc.subjectDentine
dc.subjectEnamel
dc.subjectFluoride-treated water
dc.subjectFluosilicic acid
dc.subjectLead toxicity
dc.subjectEnvironment
dc.titleFluoride increases lead concentrations in whole blood and in calcified tissues from lead-exposed rats
dc.typeArtículos de revistas


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