dc.creator | BONAVENTURA, Daniella | |
dc.creator | TIRAPELLI, Carlos R. | |
dc.creator | OLIVEIRA, Ana Maria de | |
dc.date.accessioned | 2012-10-19T03:40:32Z | |
dc.date.accessioned | 2018-07-04T14:57:33Z | |
dc.date.available | 2012-10-19T03:40:32Z | |
dc.date.available | 2018-07-04T14:57:33Z | |
dc.date.created | 2012-10-19T03:40:32Z | |
dc.date.issued | 2009 | |
dc.identifier | AMINO ACIDS, v.37, n.4, p.617-627, 2009 | |
dc.identifier | 0939-4451 | |
dc.identifier | http://producao.usp.br/handle/BDPI/20026 | |
dc.identifier | 10.1007/s00726-008-0181-z | |
dc.identifier | http://dx.doi.org/10.1007/s00726-008-0181-z | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1616810 | |
dc.description.abstract | This study investigates the effects of chronic methionine intake on bradykinin (BK)-relaxation. Vascular reactivity experiments were performed on carotid rings from male Wistar rats. Treatment with methionine (0.1, 1 or 2 g kg(-1) per day) for 8 and 16 weeks, but not for 2 and 4 weeks, reduced the relaxation induced by BK. Indomethacin, a non-selective cyclooxygenase (COX) inhibitor, and SQ29548, a selective thromboxane A(2) (TXA(2))/prostaglandin H(2) (PGH(2)) receptor antagonist prevented the reduction in BK-relaxation observed in the carotid from methionine-treated rats. Conversely, AH6809, a selective prostaglandin F(2 alpha) (PGF(2 alpha)) receptor antagonist did not alter BK-relaxation in the carotid from methionine-treated rats. The nitric oxide synthase (NOS) inhibitors L-NAME, L-NNA and 7-nitroindazole reduced the relaxation induced by BK in carotids from control and methionine-treated rats. In summary, we found that chronic methionine intake impairs the endothelium-dependent relaxation induced by BK and this effect is due to an increased production of endothelial vasoconstrictor prostanoids (possibly TXA(2)) that counteracts the relaxant action displayed by the peptide. | |
dc.language | eng | |
dc.publisher | SPRINGER | |
dc.relation | Amino Acids | |
dc.rights | Copyright SPRINGER | |
dc.rights | restrictedAccess | |
dc.subject | Methionine | |
dc.subject | Homocysteine | |
dc.subject | Bradykinin | |
dc.subject | Relaxation | |
dc.subject | Prostanoids | |
dc.title | Chronic methionine load-induced hyperhomocysteinemia impairs the relaxation induced by bradykinin in the isolated rat carotid | |
dc.type | Artículos de revistas | |