dc.creatorBONAVENTURA, Daniella
dc.creatorTIRAPELLI, Carlos R.
dc.creatorOLIVEIRA, Ana Maria de
dc.date.accessioned2012-10-19T03:40:32Z
dc.date.accessioned2018-07-04T14:57:33Z
dc.date.available2012-10-19T03:40:32Z
dc.date.available2018-07-04T14:57:33Z
dc.date.created2012-10-19T03:40:32Z
dc.date.issued2009
dc.identifierAMINO ACIDS, v.37, n.4, p.617-627, 2009
dc.identifier0939-4451
dc.identifierhttp://producao.usp.br/handle/BDPI/20026
dc.identifier10.1007/s00726-008-0181-z
dc.identifierhttp://dx.doi.org/10.1007/s00726-008-0181-z
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1616810
dc.description.abstractThis study investigates the effects of chronic methionine intake on bradykinin (BK)-relaxation. Vascular reactivity experiments were performed on carotid rings from male Wistar rats. Treatment with methionine (0.1, 1 or 2 g kg(-1) per day) for 8 and 16 weeks, but not for 2 and 4 weeks, reduced the relaxation induced by BK. Indomethacin, a non-selective cyclooxygenase (COX) inhibitor, and SQ29548, a selective thromboxane A(2) (TXA(2))/prostaglandin H(2) (PGH(2)) receptor antagonist prevented the reduction in BK-relaxation observed in the carotid from methionine-treated rats. Conversely, AH6809, a selective prostaglandin F(2 alpha) (PGF(2 alpha)) receptor antagonist did not alter BK-relaxation in the carotid from methionine-treated rats. The nitric oxide synthase (NOS) inhibitors L-NAME, L-NNA and 7-nitroindazole reduced the relaxation induced by BK in carotids from control and methionine-treated rats. In summary, we found that chronic methionine intake impairs the endothelium-dependent relaxation induced by BK and this effect is due to an increased production of endothelial vasoconstrictor prostanoids (possibly TXA(2)) that counteracts the relaxant action displayed by the peptide.
dc.languageeng
dc.publisherSPRINGER
dc.relationAmino Acids
dc.rightsCopyright SPRINGER
dc.rightsrestrictedAccess
dc.subjectMethionine
dc.subjectHomocysteine
dc.subjectBradykinin
dc.subjectRelaxation
dc.subjectProstanoids
dc.titleChronic methionine load-induced hyperhomocysteinemia impairs the relaxation induced by bradykinin in the isolated rat carotid
dc.typeArtículos de revistas


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