Artículos de revistas
Validation of an HPLC analytical method for determination of pancuronium bromide in pharmaceutical injections
Fecha
2008Registro en:
ANALYTICAL LETTERS, v.41, n.10, p.1895-1908, 2008
0003-2719
10.1080/00032710802162095
Autor
GARCIA, Pedro Lopez
GOMES, Fabio Pereira
ROCHA, Maria Ines
SANTORO, Miritello
KEDOR-HACKMANN, Erika Rosa Maria
Institución
Resumen
Pancuronium bromide is used with general anesthesia in surgery for muscle relaxation and as an aid to intubation. A high performance liquid chromatographic method was fully validated for the quantitative determination of pancuronium bromide in pharmaceutical injectable solutions. The analytical method was performed on an amino column (Luna 150mm4.6mm, 5m). The mobile phase was composed of acetonitrile:water containing 50mmol L-1 of 1-octane sulfonic acid sodium salt (20:80v/v) with a flow rate of 1.0mL min-1 and ultraviolet (UV) detection at 210nm. The proposed analytical method was compared with that described in the British Pharmacopoeia.