Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides

dc.creatorRANDO, Daniela G.
dc.creatorAVERY, Mitchell A.
dc.creatorTEKWANI, Babu L.
dc.creatorKHAN, Shabana I.
dc.creatorFERREIRA, Elizabeth I.
dc.date.accessioned2012-10-19T03:17:42Z
dc.date.accessioned2018-07-04T14:56:10Z
dc.date.available2012-10-19T03:17:42Z
dc.date.available2018-07-04T14:56:10Z
dc.date.created2012-10-19T03:17:42Z
dc.date.issued2008
dc.identifierBIOORGANIC & MEDICINAL CHEMISTRY, v.16, n.14, p.6724-6731, 2008
dc.identifier0968-0896
dc.identifierhttp://producao.usp.br/handle/BDPI/19714
dc.identifier10.1016/j.bmc.2008.05.076
dc.identifierhttp://dx.doi.org/10.1016/j.bmc.2008.05.076
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1616501
dc.description.abstractA series of 53 nitro derivatives rationally designed were obtained by parallel synthesis and screened against Leishmania donovani. Six compounds exhibited IC(50) values lower than standard drugs. Brief SAR analysis revealed that substitution is important to the activity. Nitrothiophene analogues were more potent than the nitrofuran ones. This was attributed to the ability of sulfur atoms in accommodating electrons from nitro group, which facilitate its reduction and therefore the formation of free radicals lethal to parasites. (c) 2008 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relationBioorganic & Medicinal Chemistry
dc.rightsCopyright PERGAMON-ELSEVIER SCIENCE LTD
dc.rightsrestrictedAccess
dc.subjectnitroderivatives
dc.subjectantileishmanial agents
dc.subjectparallel synthesis
dc.subjectSAR
dc.titleAntileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides
dc.typeArtículos de revistas


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