dc.creator | VINOLO, Marco Aurelio Ramirez | |
dc.creator | CRISMA, Amanda Rabello | |
dc.creator | NAKAJIMA, Karina | |
dc.creator | ROGERO, Marcelo Macedo | |
dc.creator | FOCK, Ricardo Ambrosio | |
dc.creator | BORELLI, Primavera | |
dc.date.accessioned | 2012-10-19T03:17:04Z | |
dc.date.accessioned | 2018-07-04T14:55:50Z | |
dc.date.available | 2012-10-19T03:17:04Z | |
dc.date.available | 2018-07-04T14:55:50Z | |
dc.date.created | 2012-10-19T03:17:04Z | |
dc.date.issued | 2008 | |
dc.identifier | NUTRITION RESEARCH, v.28, n.11, p.791-797, 2008 | |
dc.identifier | 0271-5317 | |
dc.identifier | http://producao.usp.br/handle/BDPI/19639 | |
dc.identifier | 10.1016/j.nutres.2008.08.006 | |
dc.identifier | http://dx.doi.org/10.1016/j.nutres.2008.08.006 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1616426 | |
dc.description.abstract | The aim of this Study was to determine if protein-energy malnutrition Could affect the hematologic response to granulocyte colony-stimulating factor (G-CSF). Swiss mice were fled a low-protein diet containing 4% protein, whereas control mice were fed a 20% protein-containing diet. After the malnourished group lost 20% of their original body weight, the mice were subdivided in 2 treatment groups, and hematopoietic parameters were studied. Mice were injected with either 8 mu g/kg per day of G-CSF or saline twice daily for 4 days. Malnourished mice developed anemia with reticulopenia and leukopenia with depletion of granulocytes and lymphocytes. Both malnourished and control mice treated with G-CSF showed a significant increase in neutrophils; however, in the control group, this increase was more pronounced compared to the malnourished group (4.5-fold and 3.4-fold, respectively). Granulocyte colony-stimulating factor administration increased bone marrow blastic (P < .001) and granulocytic (P < .01) compartments in the controls bill had no significant effect oil these hematopoietic compartments in the Malnourished animals (P = .08 and P = .62, respectively). We report that malnourished mice display an impaired response to G-CSF, which contributes to the decreased production of leukocytes in protein-energy malnutrition. (C) 2008 Elsevier Inc. All rights reserved. | |
dc.language | eng | |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | |
dc.relation | Nutrition Research | |
dc.rights | Copyright PERGAMON-ELSEVIER SCIENCE LTD | |
dc.rights | restrictedAccess | |
dc.subject | Protein-energy malnutrition | |
dc.subject | Hematopoiesis | |
dc.subject | G-CSF | |
dc.subject | Leukocytes | |
dc.subject | Mice | |
dc.title | Malnourished mice display an impaired hematologic response to granulocyte colony-stimulating factor administration | |
dc.type | Artículos de revistas | |