Artículos de revistas
Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality
Fecha
2011Registro en:
EUROPEAN HEART JOURNAL, v.32, n.7, p.904-912, 2011
0195-668X
10.1093/eurheartj/ehq244
Autor
Jorge, Luciana
Rodrigues, Bruno
Rosa, Kaleizu Teodoro
Malfitano, Christiane
Loureiro, Tatiana Carolina Alba
Medeiros, Alessandra
Curi, Rui
Brum, Patricia Chakur
Lacchini, Silvia
Montano, Nicola
Angelis, Katia De
Irigoyen, Maria Claudia
Institución
Resumen
Aims To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO(2) max), and mortality after myocardial infarction (MI) in rats. Methods and results Male Wistar rats were divided into: control (C), sedentary-infarcted (SI), and trained-infarcted (TI). One week after MI, TI group underwent an ET protocol (90 days, 50-70% VO2 max). Left ventricular function was evaluated noninvasively and invasively. Baroreflex sensitivity, heart rate variability, and pulse interval were measured. Cardiac output (CO) and regional BFs were determined using coloured microspheres. Infarcted area was reduced in TI (19 +/- 6%) compared with SI (34 +/- 5%) after ET. Exercise training improved the LV and autonomic functions, the CO and regional BF changes induced by MI, as well as increased SERCA2 expression and mRNA vascular endothelial growth factor levels. These changes brought about by ET resulted in mortality rate reduction in the TI (13%) group compared with the SI (54%) group. Conclusion Early aerobic ET reduced cardiac and peripheral dysfunctions and preserved cardiovascular autonomic control after MI in trained rats. Consequently, these ET-induced changes resulted in improved functional capacity and survival after MI.