Viral mutation and its influence in the time evolution of the immunizations

dc.creatorCASTRO, A. de
dc.creatorALVES, D.
dc.date.accessioned2012-04-18T21:57:08Z
dc.date.accessioned2018-07-04T14:35:42Z
dc.date.available2012-04-18T21:57:08Z
dc.date.available2018-07-04T14:35:42Z
dc.date.created2012-04-18T21:57:08Z
dc.date.issued2009
dc.identifierEUROPEAN PHYSICAL JOURNAL-APPLIED PHYSICS, v.47, n.3, 2009
dc.identifier1286-0042
dc.identifierhttp://producao.usp.br/handle/BDPI/15348
dc.identifier10.1051/epjap/2009098
dc.identifierhttp://dx.doi.org/10.1051/epjap/2009098
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1612187
dc.description.abstractIn this paper, we study the behavior of immune memory against antigenic mutation. Using a dynamic model proposed by one of the authors in a previous study (A. de Castro [Phys. J. Appl. Phys. 33, 147 (2006) and Simul. Mod. Pract. Theory. 15, 831 (2007)]), we have performed simulations of several inoculations, where in each virtual sample the viral population undergoes mutations. Our results suggest that the sustainability of the immunizations is dependent on viral variability and that the memory lifetimes are not random, what contradicts what was suggested by Tarlinton et al. [Curr. Opin. Immunol. 20, 162 (2008)]. We show that what may cause an apparent random behavior of the immune memory is the antigenic variability.
dc.languageeng
dc.publisherEDP SCIENCES S A
dc.relationEuropean Physical Journal-applied Physics
dc.rightsCopyright EDP SCIENCES S A
dc.rightsopenAccess
dc.titleViral mutation and its influence in the time evolution of the immunizations
dc.typeArtículos de revistas


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