dc.creator | SOARES, S. C. | |
dc.creator | ABE-SANDES, K. | |
dc.creator | NASCIMENTO FILHO, V. B. | |
dc.creator | NUNES, F. M. F. | |
dc.creator | SILVA JR., W. A. | |
dc.date.accessioned | 2012-04-18T21:56:18Z | |
dc.date.accessioned | 2018-07-04T14:35:37Z | |
dc.date.available | 2012-04-18T21:56:18Z | |
dc.date.available | 2018-07-04T14:35:37Z | |
dc.date.created | 2012-04-18T21:56:18Z | |
dc.date.issued | 2008 | |
dc.identifier | GENETICS AND MOLECULAR RESEARCH, v.7, n.4, p.1011-1019, 2008 | |
dc.identifier | 1676-5680 | |
dc.identifier | http://producao.usp.br/handle/BDPI/15327 | |
dc.identifier | http://www.geneticsmr.com//year2008/vol7-4/pdf/gmr439.pdf | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1612166 | |
dc.description.abstract | The main purpose of this research was to analyze the relation of the genetic polymorphisms frequently expressed by antigen-presenting cells, erythrocytes and malaria susceptibility/resistance with the human malaria infection cases. The sample used consisted of 23 Plasmodium vivax ( Pv)- and P. falciparum ( Pf)-infected patients, and 21 healthy individuals as a control group, from the Baixo Amazonas population in Para, Brazil. The Asp299Gly polymorphisms in the Toll-like receptor 4 ( TLR4), and Gly42Asp, Arg89Cys, Ala100Thr, and T-33C in the Duffy gene ( FY) were analyzed by restriction fragment length polymorphism-polymerase chain reaction. The Lys1590Glu and Arg1601Gly polymorphisms in the complement receptor type 1 (CR1) were analyzed by DNA sequencing. According to the results obtained and statistical analysis considering a significance level or alpha = 0.01, we conclude that the low heterozygote frequency (2.27%) for the Asp299Gly mutation, detected in the TLR4 gene, is not related to the Pv and Pf infections in the patients analyzed. Also, the promoter region GATA-1 analysis of the FY gene in the Pv-infected patients showed that the heterozygote frequency for the T-33C mutation (11.36% of the infected patients and 20.45% of the control patients) is not related to infection resistance. Regarding the CR1 gene, the observed heterozygote frequency (9.09%) for the Arg1601Gly mutation in Pf-infected patients when compared to heterozygote frequency in the control group (18.18%) suggests that there is no correlation with infection resistance. | |
dc.language | eng | |
dc.publisher | FUNPEC-EDITORA | |
dc.relation | Genetics and Molecular Research | |
dc.rights | Copyright FUNPEC-EDITORA | |
dc.rights | openAccess | |
dc.subject | Malaria | |
dc.subject | Complement receptor-1 | |
dc.subject | Toll-like receptor | |
dc.subject | Duffy blood group | |
dc.subject | Genetic polymorphisms | |
dc.subject | Brazilian population | |
dc.title | Genetic polymorphisms in TLR4, CR1 and Duffy genes are not associated with malaria resistance in patients from Baixo Amazonas region, Brazil | |
dc.type | Artículos de revistas | |