dc.creatorBURANELLO, Patricia Andressa de Almeida
dc.creatorMOULIN, Maria Raquel Isnard
dc.creatorSOUZA JR., Devandir Antonio
dc.creatorJAMUR, Maria Celia
dc.creatorROQUE-BARREIRA, Maria Cristina
dc.creatorOLIVER, Constance
dc.date.accessioned2012-04-18T21:54:06Z
dc.date.accessioned2018-07-04T14:35:22Z
dc.date.available2012-04-18T21:54:06Z
dc.date.available2018-07-04T14:35:22Z
dc.date.created2012-04-18T21:54:06Z
dc.date.issued2010
dc.identifierPLOS ONE, v.5, n.3, 2010
dc.identifier1932-6203
dc.identifierhttp://producao.usp.br/handle/BDPI/15275
dc.identifier10.1371/journal.pone.0009776
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0009776
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1612115
dc.description.abstractBackground: The D-mannose binding lectin ArtinM is known to recruit neutrophils, to degranulate mast cells and may have potential therapeutic applications. However, the effect of ArtinM on mast cell recruitment has not been investigated. Methodology: Male Wistar rats were injected i.p. with ArtinM or ConA (control). The ability of the lectin to degranulate peritoneal and mesenteric mast cells was examined. Recruitment of mast cells to the peritoneal cavity and mesentery after ArtinM injection was examined with or without depletion of peritoneal mast cells by distilled water. Results: ArtinM degranulated both peritoneal and mesentery mast cells in vitro. Three days after i.p. injection of the lectin there were reduced numbers of mast cells in the peritoneal lavage, while at 7 days post injection of ArtinM, the number of peritoneal mast cells was close to control values. Since immature mast cells are recruited from the bone marrow, the effect of the lectin on bone marrow mast cells was examined. Injection of ArtinM resulted in an increased number of mast cells in the bone marrow. To determine if degranulation of mast cells in the peritoneal cavity was required for the increase in bone marrow mast cells, the peritoneal cavity was depleted of mast cells with ultrapure water. Exposure to ArtinM increased the number of mast cells in the bone marrow of rats depleted of peritoneal mast cells. Conclusions: The ArtinM induced recruitment of mast cells from the bone marrow to the peritoneal cavity may partially explain the therapeutic actions of ArtinM.
dc.languageeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.relationPlos One
dc.rightsCopyright PUBLIC LIBRARY SCIENCE
dc.rightsopenAccess
dc.titleThe Lectin ArtinM Induces Recruitment of Rat Mast Cells from the Bone Marrow to the Peritoneal Cavity
dc.typeArtículos de revistas


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