Brasil | Artículos de revistas
dc.creatorRODRIGUES, Alice C.
dc.creatorPERIN, Paula M. S.
dc.creatorPURIM, Sheila G.
dc.creatorSILBIGER, Vivian N.
dc.creatorGENVIGIR, Fabiana D. V.
dc.creatorWILLRICH, Maria Alice V.
dc.creatorARAZI, Simone S.
dc.creatorLUCHESSI, Andre D.
dc.creatorHIRATA, Mario H.
dc.creatorBERNIK, Marcia M. S.
dc.creatorDOREA, Egidio L.
dc.creatorSANTOS, Carla
dc.creatorFALUDI, Andre A.
dc.creatorBERTOLAMI, Marcelo C.
dc.creatorSALAS, Antonio
dc.creatorFREIRE, Ana
dc.creatorLAREU, Maria V.
dc.creatorPHILLIPS, Christopher
dc.creatorPORRAS-HURTADO, Liliana
dc.creatorFONDEVILA, Manuel
dc.creatorCARRACEDO, Angel
dc.creatorHIRATA, Rosario D. C.
dc.date.accessioned2012-04-17T22:56:13Z
dc.date.accessioned2018-07-04T14:33:24Z
dc.date.available2012-04-17T22:56:13Z
dc.date.available2018-07-04T14:33:24Z
dc.date.created2012-04-17T22:56:13Z
dc.date.issued2011
dc.identifierINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.12, n.9, p.5815-5827, 2011
dc.identifier1661-6596
dc.identifierhttp://producao.usp.br/handle/BDPI/14811
dc.identifier10.3390/ijms12095815
dc.identifierhttp://dx.doi.org/10.3390/ijms12095815
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1611659
dc.description.abstractAims: The relationship between variants in SLCO1B1 and SLCO2B1 genes and lipid-lowering response to atorvastatin was investigated. Material and Methods: One-hundred-thirty-six unrelated individuals with hypercholesterolemia were selected and treated with atorvastatin (10 mg/day/4 weeks). They were genotyped with a panel of ancestry informative markers for individual African component of ancestry (ACA) estimation by SNaPshot (R) and SLCO1B1 (c.388A>G, c.463C>A and c.521T>C) and SLCO2B1 (-71T>C) gene polymorphisms were identified by TaqMan (R) Real-time PCR. Results: Subjects carrying SLCO1B1 c.388GG genotype exhibited significantly high low-density lipoprotein (LDL) cholesterol reduction relative to c.388AA+c.388AG carriers (41 vs. 37%, p = 0.034). Haplotype analysis revealed that homozygous of SLCO1B1*15 (c.521C and c.388G) variant had similar response to statin relative to heterozygous and non-carriers. A multivariate logistic regression analysis confirmed that c.388GG genotype was associated with higher LDL cholesterol reduction in the study population (OR: 3.2, CI95%: 1.3-8.0, p < 0.05). Conclusion: SLCO1B1 c.388A>G polymorphism causes significant increase in atorvastatin response and may be an important marker for predicting efficacy of lipid-lowering therapy.
dc.languageeng
dc.publisherMDPI AG
dc.relationInternational Journal of Molecular Sciences
dc.rightsCopyright MDPI AG
dc.rightsopenAccess
dc.subjectOATP
dc.subjectatorvastatin
dc.subjectsingle nucleotide polymorphisms
dc.subjectpharmacogenetics
dc.titlePharmacogenetics of OATP Transporters Reveals That SLCO1B1 c.388A > G Variant Is Determinant of Increased Atorvastatin Response
dc.typeArtículos de revistas


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