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| Artículos de revistas
Pharmacogenetics of OATP Transporters Reveals That SLCO1B1 c.388A > G Variant Is Determinant of Increased Atorvastatin Response
dc.creator | RODRIGUES, Alice C. | |
dc.creator | PERIN, Paula M. S. | |
dc.creator | PURIM, Sheila G. | |
dc.creator | SILBIGER, Vivian N. | |
dc.creator | GENVIGIR, Fabiana D. V. | |
dc.creator | WILLRICH, Maria Alice V. | |
dc.creator | ARAZI, Simone S. | |
dc.creator | LUCHESSI, Andre D. | |
dc.creator | HIRATA, Mario H. | |
dc.creator | BERNIK, Marcia M. S. | |
dc.creator | DOREA, Egidio L. | |
dc.creator | SANTOS, Carla | |
dc.creator | FALUDI, Andre A. | |
dc.creator | BERTOLAMI, Marcelo C. | |
dc.creator | SALAS, Antonio | |
dc.creator | FREIRE, Ana | |
dc.creator | LAREU, Maria V. | |
dc.creator | PHILLIPS, Christopher | |
dc.creator | PORRAS-HURTADO, Liliana | |
dc.creator | FONDEVILA, Manuel | |
dc.creator | CARRACEDO, Angel | |
dc.creator | HIRATA, Rosario D. C. | |
dc.date.accessioned | 2012-04-17T22:56:13Z | |
dc.date.accessioned | 2018-07-04T14:33:24Z | |
dc.date.available | 2012-04-17T22:56:13Z | |
dc.date.available | 2018-07-04T14:33:24Z | |
dc.date.created | 2012-04-17T22:56:13Z | |
dc.date.issued | 2011 | |
dc.identifier | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.12, n.9, p.5815-5827, 2011 | |
dc.identifier | 1661-6596 | |
dc.identifier | http://producao.usp.br/handle/BDPI/14811 | |
dc.identifier | 10.3390/ijms12095815 | |
dc.identifier | http://dx.doi.org/10.3390/ijms12095815 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1611659 | |
dc.description.abstract | Aims: The relationship between variants in SLCO1B1 and SLCO2B1 genes and lipid-lowering response to atorvastatin was investigated. Material and Methods: One-hundred-thirty-six unrelated individuals with hypercholesterolemia were selected and treated with atorvastatin (10 mg/day/4 weeks). They were genotyped with a panel of ancestry informative markers for individual African component of ancestry (ACA) estimation by SNaPshot (R) and SLCO1B1 (c.388A>G, c.463C>A and c.521T>C) and SLCO2B1 (-71T>C) gene polymorphisms were identified by TaqMan (R) Real-time PCR. Results: Subjects carrying SLCO1B1 c.388GG genotype exhibited significantly high low-density lipoprotein (LDL) cholesterol reduction relative to c.388AA+c.388AG carriers (41 vs. 37%, p = 0.034). Haplotype analysis revealed that homozygous of SLCO1B1*15 (c.521C and c.388G) variant had similar response to statin relative to heterozygous and non-carriers. A multivariate logistic regression analysis confirmed that c.388GG genotype was associated with higher LDL cholesterol reduction in the study population (OR: 3.2, CI95%: 1.3-8.0, p < 0.05). Conclusion: SLCO1B1 c.388A>G polymorphism causes significant increase in atorvastatin response and may be an important marker for predicting efficacy of lipid-lowering therapy. | |
dc.language | eng | |
dc.publisher | MDPI AG | |
dc.relation | International Journal of Molecular Sciences | |
dc.rights | Copyright MDPI AG | |
dc.rights | openAccess | |
dc.subject | OATP | |
dc.subject | atorvastatin | |
dc.subject | single nucleotide polymorphisms | |
dc.subject | pharmacogenetics | |
dc.title | Pharmacogenetics of OATP Transporters Reveals That SLCO1B1 c.388A > G Variant Is Determinant of Increased Atorvastatin Response | |
dc.type | Artículos de revistas |