Artículos de revistas
Determination of 5-aminosalicylic acid in pharmaceutical formulations by square wave voltammetry at pencil graphite electrodes
Fecha
2010Registro en:
Química Nova, v.33, n.4, p.964-967, 2010
0100-4042
10.1590/S0100-40422010000400036
Autor
ULIANA, Carolina V.
YAMANAKA, Hideko
GARBELLINI, Gustavo S.
SALAZAR-BANDA, Giancarlo R.
Institución
Resumen
An analytical method for the determination of the anti-inflammatory drug 5-aminosalicylic acid (5-ASA) in pharmaceutical formulations using square wave voltammetry at pencil graphite electrodes was developed. After the optimization of the experimental conditions, calibration curves were obtained in the linear concentration range from 9.78 × 10-7 to 7.25 × 10-5 mol L-1 resulting in a limit of detection of 2.12 ± 0.05 x 10-8 mol L-1. Statistical tests showed that the concentrations of 5-ASA in commercial tablets and enemas obtained with the proposed voltammetric method agreed with HPLC values at a 95% confidence level.