dc.creator | SOUZA, Yglesio Moyses de | |
dc.creator | FONTES, Belchor | |
dc.creator | MARTINS, Joilson O | |
dc.creator | SANNOMIYA, Paulina | |
dc.creator | BRITO, Glacus S. | |
dc.creator | YOUNES, Riad N. | |
dc.creator | RASSLAN, Samir | |
dc.date.accessioned | 2012-03-26T21:25:44Z | |
dc.date.accessioned | 2018-07-04T14:23:54Z | |
dc.date.available | 2012-03-26T21:25:44Z | |
dc.date.available | 2018-07-04T14:23:54Z | |
dc.date.created | 2012-03-26T21:25:44Z | |
dc.date.issued | 2010 | |
dc.identifier | Clinics, v.65, n.2, p.195-202, 2010 | |
dc.identifier | 1807-5932 | |
dc.identifier | http://producao.usp.br/handle/BDPI/11731 | |
dc.identifier | 10.1590/S1807-59322010000200012 | |
dc.identifier | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010000200012 | |
dc.identifier | http://www.scielo.br/pdf/clin/v65n2/a12v65n2.pdf | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1609523 | |
dc.description.abstract | INTRODUCTION: The antibacterial effect of ozone (O3) has been described in the extant literature, but the role of O3 therapy in the treatment of certain types of infection remains controversial. OBJECTIVES: To evaluate the effect of intraperitoneal (i.p.) O3 application in a cecal ligation/puncture rat model on interleukins (IL-6, IL-10) and cytokine-induced neutrophil chemoattractant (CINC)-1 serum levels, acute lung injury and survival rates. METHODS: Four animal groups were used for the study: a) the SHAM group underwent laparotomy; b) the cecal ligation/puncture group underwent cecal ligation/puncture procedures; and c) the CLP+O2 and CLP+O3 groups underwent CLP+ corresponding gas mixture infusions (i.p.) throughout the observation period. IL-6, CINC-1 and IL-10 concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Acute lung injury was evaluated with the Evans blue dye lung leakage method and by lung histology. P<0.05 was considered significant. RESULTS: CINC-1 was at the lowest level in the SHAM group and was lower for the CLP+O3 group vs. the CLP+O2 group and the cecal ligation/puncture group. IL-10 was lower for the SHAM group vs. the other three groups, which were similar compared to each other. IL-6 was lower for the SHAM group vs. all other groups, was lower for the CLP+O3 or CLP+O2 group vs. the cecal ligation/puncture group, and was similar for the CLP+O3 group vs. the CLP+O2 group. The lung histology score was lower for the SHAM group vs. the other groups. The Evans blue dye result was lower for the CLP+O3 group vs. the CLP+O2 group and the cecal ligation/puncture group but similar to that of the SHAM group. The survival rate for the CLP+O3 group was lower than for the SHAM group and similar to that for the other 2 groups (CLP and CLP+O2). CONCLUSION: Ozone therapy modulated the inflammatory response and acute lung injury in the cecal ligation/puncture infection model in rats, although there was no improvement on survival rates. | |
dc.language | eng | |
dc.publisher | Faculdade de Medicina / USP | |
dc.relation | Clinics | |
dc.rights | Copyright Faculdade de Medicina / USP | |
dc.rights | openAccess | |
dc.subject | IL-6 | |
dc.subject | IL-10 | |
dc.subject | CINC-1 | |
dc.subject | Sepsis | |
dc.subject | ALI | |
dc.subject | CLP | |
dc.title | Evaluation of the effects of ozone therapy in the treatment of intra-abdominal infection in rats | |
dc.type | Artículos de revistas | |