dc.creatorNOVIS, Maria Inês
dc.creatorBARONI, Ronaldo Hueb
dc.creatorCERRI, Luciana Mendes de Oliveira
dc.creatorMATTEDI, Romulo Loss
dc.creatorBUCHPIGUEL, Carlos Alberto
dc.date.accessioned2012-03-26T18:52:54Z
dc.date.accessioned2018-07-04T14:17:11Z
dc.date.available2012-03-26T18:52:54Z
dc.date.available2018-07-04T14:17:11Z
dc.date.created2012-03-26T18:52:54Z
dc.date.issued2011
dc.identifierClinics, v.66, n.1, p.27-34, 2011
dc.identifier1807-5932
dc.identifierhttp://producao.usp.br/handle/BDPI/10214
dc.identifier10.1590/S1807-59322011000100006
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000100006
dc.identifierhttp://www.scielo.br/pdf/clin/v66n1/v66n1a06.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1608024
dc.description.abstractOBJECTIVES: To evaluate transrectal ultrasound, amplitude Doppler ultrasound, conventional T2-weighted magnetic resonance imaging, spectroscopy and dynamic contrast-enhanced magnetic resonance imaging in localizing and locally staging low-risk prostate cancer. INTRODUCTION: Prostate cancer has been diagnosed at earlier stages and the most accepted classification for low-risk prostate cancer is based on clinical stage T1c or T2a, Gleason score <6, and prostate-specific antigen (PSA) <10 ng/ml. METHODS: From 2005 to 2006, magnetic resonance imaging was performed in 42 patients, and transrectal ultrasound in 26 of these patients. Seven patients were excluded from the study. Mean patient age was 64.94 years and mean serum PSA was 6.05 ng/ml. The examinations were analyzed for tumor identification and location in prostate sextants, detection of extracapsular extension, and seminal vesicle invasion, using surgical pathology findings as the gold standard. RESULTS: Sixteen patients (45.7%) had pathologically proven organ-confined disease, 11 (31.4%) had positive surgical margin, 8 (28.9%) had extracapsular extension, and 3 (8.6%) presented with extracapsular extension and seminal vesicle invasion. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy values for localizing low-risk prostate cancer were 53.1%, 48.3%, 63.4%, 37.8% and 51.3% for transrectal ultrasound; 70.4%, 36.2%, 65.1%, 42.0% and 57.7% for amplitude Doppler ultrasound; 71.5%, 58.9%, 76.6%, 52.4% and 67.1% for magnetic resonance imaging; 70.4%, 58.7%, 78.4%, 48.2% and 66.7% for magnetic resonance spectroscopy; 67.2%, 65.7%, 79.3%, 50.6% and 66.7% for dynamic contrast-enhanced magnetic resonance imaging, respectively. Sensitivity, specificity, PPV, NPV and accuracy values for detecting extracapsular extension were 33.3%, 92%, 14.3%, 97.2% and 89.7% for transrectal ultrasound and 50.0%, 77.6%, 13.7%, 95.6% and 75.7% for magnetic resonance imaging, respectively. For detecting seminal vesicle invasion, these values were 66.7%, 85.7%, 22.2%, 97.7% and 84.6% for transrectal ultrasound and 40.0%, 83.1%, 15.4%, 94.7% and 80.0% for magnetic resonance imaging. CONCLUSION: Although preliminary, our results suggest that imaging modalities have limited usefulness in localizing and locally staging clinically low-risk prostate cancer.
dc.languageeng
dc.publisherFaculdade de Medicina / USP
dc.relationClinics
dc.rightsCopyright Faculdade de Medicina / USP
dc.rightsopenAccess
dc.subjectProstatic neoplasm
dc.subjectCancer staging
dc.subjectMagnetic Resonance Imaging
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectUltrasonography
dc.subjectDoppler Ultrasound
dc.titleClinically low-risk prostate cancer: evaluation with transrectal doppler ultrasound and functional magnetic resonance imaging
dc.typeArtículos de revistas


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